Basic properties of ATP-induced myosin head movement in hydrated myosin filaments, studied using the gas environmental chamber.
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DOI: 10.1016/j.micron.2018.06.003
Abstract: Although more than 50 years have passed since the monumental discovery of Huxley and Hanson that muscle contraction results from relative sliding between actin and myosin filaments, coupled with ATP hydrolysis, the mechanism underlying the… read more here.
Keywords: myosin head; myosin; myosin filaments; myosin heads ... See more keywords
Molecular Mechanisms of Muscle Weakness Associated with E173A Mutation in Tpm3.12. Troponin Ca2+ Sensitivity Inhibitor W7 Can Reduce the Damaging Effect of This Mutation
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DOI: 10.3390/ijms21124421
Abstract: Substitution of Ala for Glu residue in position 173 of γ-tropomyosin (Tpm3.12) is associated with muscle weakness. Here we observe that this mutation increases myofilament Ca2+-sensitivity and inhibits in vitro actin-activated ATPase activity of myosin… read more here.
Keywords: ca2 sensitivity; muscle weakness; myosin heads; ca2 ... See more keywords
Molecular Mechanisms of Deregulation of Muscle Contractility Caused by the R168H Mutation in TPM3 and Its Attenuation by Therapeutic Agents
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DOI: 10.3390/ijms24065829
Abstract: The substitution for Arg168His (R168H) in γ-tropomyosin (TPM3 gene, Tpm3.12 isoform) is associated with congenital muscle fiber type disproportion (CFTD) and muscle weakness. It is still unclear what molecular mechanisms underlie the muscle dysfunction seen… read more here.
Keywords: tropomyosin; muscle; actin; r168h mutation ... See more keywords