A new congenital multicore titinopathy associated with fast myosin heavy chain deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51031
Abstract: Congenital titinopathies are myopathies with variable phenotypes and inheritance modes. Here, we fully characterized, using an integrated approach (deep phenotyping, muscle morphology, mRNA and protein evaluation in muscle biopsies), two siblings with congenital multicore myopathy… read more here.
Keywords: titinopathy; heavy chain; congenital multicore; myosin heavy ... See more keywords
Identification, expression and function of myosin heavy chain family genes in Tribolium castaneum.
Sign Up to like & getrecommendations! Published in 2018 at "Genomics"
DOI: 10.1016/j.ygeno.2018.04.010
Abstract: Functions of myosin heavy chain (myosin) family genes are poorly understood in some insects. To address this, we determined the expression and function of myosin family genes in Tribolium castaneum. TcMyo15 is predominantly expressed in… read more here.
Keywords: heavy chain; family; myosin heavy; family genes ... See more keywords
A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28666-1
Abstract: The contractile properties of adult myofibers are shaped by their Myosin heavy chain isoform content. Here, we identify by snATAC-seq a 42 kb super-enhancer at the locus regrouping the fast Myosin genes. By 4C-seq we show… read more here.
Keywords: myosin heavy; super enhancer; fast myosin; myosin genes ... See more keywords
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111011118
Abstract: Significance SARS-CoV-2 primarily targets the lung and enters the body through ACE2 receptors. However, the expression of ACE2 is extremely low in the airways. In this study, we utilized APEX2 proximity-labeling techniques and identified nonmuscle… read more here.
Keywords: myosin heavy; cov infection; sars cov; nonmuscle myosin ... See more keywords
Gene and protein expression of myosin heavy chain in Nellore cattle comparing growth or meat tenderness traits
Sign Up to like & getrecommendations! Published in 2019 at "Animal Biotechnology"
DOI: 10.1080/10495398.2019.1688168
Abstract: Abstract The objective was to investigate gene and protein expression of myosin heavy chain (MyHC) in Nellore cattle slaughtered at different weights (BW) or degrees of meat tenderness. Ninety animals with initial BW 370 ± 37 kg, 24 months… read more here.
Keywords: protein expression; gene protein; myosin heavy; expression myosin ... See more keywords
Association Study of Myosin Heavy Chain 15 Polymorphisms with Asthma Susceptibility in Chinese Han
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DOI: 10.1155/2019/3805405
Abstract: Background The Myosin Heavy Chain 15 gene (MYH15) is expressed in the airway epithelium and variants in the gene have been associated with airway responsiveness. The aim of this study was to perform the first… read more here.
Keywords: polymorphisms asthma; heavy chain; asthma susceptibility; study ... See more keywords
Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation.
Sign Up to like & getrecommendations! Published in 2023 at "Developmental biology"
DOI: 10.2139/ssrn.4349476
Abstract: Slow myosin heavy chain 1 (Smyhc1) is the major sarcomeric myosin driving early contraction by slow skeletal muscle fibres in zebrafish. New mutant alleles lacking a functional smyhc1 gene move poorly, but recover motility as… read more here.
Keywords: heavy chain; myofibril; muscle; myosin heavy ... See more keywords
Expression of lipid metabolism and myosin heavy chain genes in pigs is affected by genotype and dietary lysine
Sign Up to like & getrecommendations! Published in 2018 at "Genetics and Molecular Research"
DOI: 10.4238/gmr16039904
Abstract: Expression of lipid metabolism and myosin heavy chain genes was evaluated in skeletal muscle of pig’s genotypes submitted to different dietary digestible lysine contents. Fifty-two barrows and fifty gilts from three genotypes (G: Piau, Duroc… read more here.
Keywords: myhc; heavy chain; myosin heavy; expression ... See more keywords
miR-29a activates expression of α-cardiac myosin heavy chain via β1 thyroid hormone receptor in neonatal rats
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Medical Science"
DOI: 10.5114/aoms.2019.91495
Abstract: MicroRNAs (miRs) are small noncoding RNAs which are regulators of gene expression and also regulate the genes in heart tissues. The aim of the study was to evaluate the effect of miRs on the expression… read more here.
Keywords: mir 29a; heavy chain; myosin heavy; expression ... See more keywords
Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74919
Abstract: Phosphorylation and acetylation of sarcomeric proteins are important for fine-tuning myocardial contractility. Here, we used bottom-up proteomics and label-free quantification to identify novel post-translational modifications (PTMs) on β-myosin heavy chain (β-MHC) in normal and failing… read more here.
Keywords: ischemic nonischemic; heavy chain; post translational; myosin heavy ... See more keywords