Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia
Sign Up to like & getrecommendations! Published in 2019 at "GeroScience"
DOI: 10.1007/s11357-019-00072-4
Abstract: The blood-brain barrier (BBB) is critical in maintenance of brain homeostasis, and loss of its functional integrity is a key feature across a broad range of neurological insults. This includes both acute injuries such as… read more here.
Keywords: myosin light; neuroinflammation; vascular cognitive; cognitive impairment ... See more keywords
The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.11.014
Abstract: Small-molecule chemotypes with unexpected bioactivity may be identified by combining strategies built on the biological relevance of, e.g., natural products (NPs), such as biology-oriented synthesis, with principles that enable efficient coverage of chemical space, such… read more here.
Keywords: inhibitor; myosin light; kinase; biology ... See more keywords
Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2017.04.002
Abstract: Myosin is the principal component of the thick filaments that, through interactions with the actin thin filaments, mediates force production during muscle contraction. Myosin is a hexamer, consisting of two heavy chains, each associated with… read more here.
Keywords: myosin light; myosin; mass spectrometry; post translational ... See more keywords
MYOSIN LIGHT CHAIN DEPHOSPHORYLATION BY PPP1R12C PROMOTES ATRIAL HYPOCONTRACTILITY IN ATRIAL FIBRILLATION
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(20)31000-7
Abstract: Atrial fibrillation (AF) increases stroke risk five-fold. Atrial hypocontractility from atrial myosin light chain (MLC2a) dephosphorylation contributes to stroke risk in AF. Recent proteomic data has shown increased protein phosphatase 1 subunit 12C (PPP1R12C) targeting… read more here.
Keywords: atrial fibrillation; atrial hypocontractility; myosin light; hypocontractility atrial ... See more keywords
Human cardiac myosin light chain 4 (MYL4) mosaic expression patterns vary by sex
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DOI: 10.1038/s41598-019-49191-0
Abstract: Sex disparities modulate cardiac function, although the proteins and mechanisms remain to be elucidated. We recently demonstrated a mosaic pattern of protein expression in the heart for over 100 proteins. Here we investigate one of… read more here.
Keywords: myosin light; sex; expression; light chain ... See more keywords
Myosin light chain kinase regulates intestinal permeability of mucosal homeostasis in Crohn’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1850269
Abstract: ABSTRACT Introduction: Researchers have investigated the potential role of intestinal permeability in Crohn’s disease pathogenesis. Intestinal permeability is usually mediated by cytoskeleton and intercellular junctions. The myosin light chain kinase (MLCK) is an enzyme that… read more here.
Keywords: intestinal permeability; myosin light; crohn disease;
The myosin light-chain kinase MLCK-1 relocalizes during Caenorhabditis elegans ovulation to promote actomyosin bundle assembly and drive contraction
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-01-0056
Abstract: We identify the Caenorhabditis elegans myosin light-chain kinase, MLCK-1, required for contraction of spermathecae. During contraction, MLCK-1 moves from the apical cell boundaries to the basal actomyosin bundles, where it stabilizes myosin downstream of calcium… read more here.
Keywords: myosin light; caenorhabditis elegans; chain kinase; contraction ... See more keywords
Membrane Permeant Inhibitor of Myosin Light Chain Kinase Worsens Survival in Murine Polymicrobial Sepsis.
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DOI: 10.1097/shk.0000000000001759
Abstract: ABSTRACT Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal hyperpermeability and improves… read more here.
Keywords: light chain; myosin; sepsis; pik ... See more keywords
Myosin Light Chain Kinase Modulates to Improve Myocardial Hypoxia/Reoxygenation Injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/8124343
Abstract: Objective The aim of this study was to evaluate whether myosin light chain kinase (MLCK) knockdown attenuated H9C2 cell hypoxia/reoxygenation (H/R) injury and downstream signaling pathway. Methods The MLCK expression in H/R injury model H9C2… read more here.
Keywords: light chain; chain kinase; p38; hypoxia reoxygenation ... See more keywords
Myosin light chain kinase (MYLK) coding polymorphisms modulate human lung endothelial cell barrier responses via altered tyrosine phosphorylation, spatial localization, and lamellipodial protrusions
Sign Up to like & getrecommendations! Published in 2018 at "Pulmonary Circulation"
DOI: 10.1177/2045894018764171
Abstract: Sphingosine 1-phosphate (S1P) is a potent bioactive endogenous lipid that signals a rearrangement of the actin cytoskeleton via the regulation of non-muscle myosin light chain kinase isoform (nmMLCK). S1P induces critical nmMLCK Y464 and Y471… read more here.
Keywords: myosin light; mylk; mylk coding; light chain ... See more keywords
Changes in serum cardiac myosin light chain 1 levels in children with fulminant myocarditis during continuous blood purification.
Sign Up to like & getrecommendations! Published in 2017 at "Revista da Associacao Medica Brasileira"
DOI: 10.1590/1806-9282.63.10.904
Abstract: OBJECTIVE To investigate the changes in serum cardiac myosin light chain 1 (CMLC-1) levels in children with fulminant myocarditis (FM) during continuous blood purification (CBP), as well as to analyze its correlation with other laboratory… read more here.
Keywords: myosin light; changes serum; light chain; levels children ... See more keywords