Simulated actin reorganization mediated by motor proteins
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010026
Abstract: Cortical actin networks are highly dynamic and play critical roles in shaping the mechanical properties of cells. The actin cytoskeleton undergoes significant reorganization in many different contexts, including during directed cell migration and over the… read more here.
Keywords: reorganization; actin myosin; simulated actin; motor ... See more keywords
Omecamtiv Mecarbil: A Myosin Motor Activator Agent with Promising Clinical Performance and New in vitro Results.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666171222164320
Abstract: BACKGROUND Clinical treatment of heart failure is still suffering from limited efficacy and unfavorable side effects. The recently developed group of agents, the myosin motor activators, act directly on cardiac myosin resulting in an increased… read more here.
Keywords: omecamtiv mecarbil; promising clinical; new vitro; effect ... See more keywords
Conformational distributions of isolated myosin motor domains encode their mechanochemical properties
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.55132
Abstract: Myosin motor domains perform an extraordinary diversity of biological functions despite sharing a common mechanochemical cycle. Motors are adapted to their function, in part, by tuning the thermodynamics and kinetics of steps in this cycle.… read more here.
Keywords: isolated myosin; distributions isolated; myosin motor; motor domains ... See more keywords