Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172616
Abstract: Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in 2-dimensional (2D) and 3-dimensional… read more here.
Keywords: myotoxicity; simvastatin induced; c2c12; simvastatin myotoxicity ... See more keywords
Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin‐induced myotoxicity
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DOI: 10.1016/j.ejps.2017.01.018
Abstract: &NA; The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid‐base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles.… read more here.
Keywords: alone combination; hyperlipidaemia alone; myotoxicity; statin ... See more keywords
Current insights into cellular senescence and myotoxicity induced by doxorubicin.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of sports medicine"
DOI: 10.1055/a-1797-7622
Abstract: Doxorubicin is an anti-neoplasmic drug that prevents DNA replication but induces senescence and cellular toxicity. Intensive research has focused on strategies to alleviate the doxorubicin-induced skeletal myotoxicity. The aim of the present review is to… read more here.
Keywords: senescence myotoxicity; current insights; cellular senescence; myotoxicity ... See more keywords
Prospective study of a Bothrops jararacussu venom batch (Bj2015) – phospholipase A2 activity, immunogenicity, neurotoxicity, and myotoxicity parameters
Sign Up to like & getrecommendations! Published in 2019 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1446010
Abstract: Abstract Bothrops jararacussu venom’s (Bj2015) batch was biomonitored quarterly for one year to assess phospholipase A2 (PLA2) activity, immunogenicity, neurotoxicity, and myotoxicity. In silico models were applied to evaluate losses using decay model and recoveries… read more here.
Keywords: immunogenicity; myotoxicity; bj2015; bothrops jararacussu ... See more keywords