Effects of serine palmitoyltransferase inhibition by myriocin in ad libitum-fed and nutrient-restricted ewes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of animal science"
DOI: 10.1093/jas/skab221
Abstract: The fungal isolate myriocin inhibits serine palmitoyltransferase and de novo ceramide synthesis in rodents; however, the effects of myriocin on ceramide concentrations and metabolism have not been previously investigated in ruminants. In our study, twelve… read more here.
Keywords: ceramide; nutrient restriction; serine palmitoyltransferase; myriocin ... See more keywords
Inhibition of Ceramide Decreased the Expression of ATP-Binding Cassette Transporter G5/8 mRNA in an Animal Model of Cholesterol Gallstone
Sign Up to like & getrecommendations! Published in 2017 at "Digestive Diseases"
DOI: 10.1159/000465517
Abstract: Background: The increased risk of gallstone has been reported in patients with ATP-binding cassette (ABC) transporter polymorphism. The half-transporters ABCG5 and ABCG8 mediate the efflux of cholesterol in hepatocytes and the intestine. We investigated whether… read more here.
Keywords: myriocin; group; cholesterol; cholesterol gallstone ... See more keywords
Myriocin alleviates Oleic/Palmitate induced chondrocyte degeneration via the suppression of ceramide.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202012_24197
Abstract: OBJECTIVE Abnormal lipid metabolism plays a role that cannot be ignored in articular cartilage bone marrow lesions, synovial inflammation, and the destruction of chondrocytes (CHs). Ceramide is one of the key constructions of membrane lipid… read more here.
Keywords: via suppression; ceramide; suppression ceramide; degeneration ... See more keywords
Myriocin Effect on Tvrm4 Retina, an Autosomal Dominant Pattern of Retinitis Pigmentosa
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2020.00372
Abstract: Tvrm4 mice, a model of autosomal dominant retinitis pigmentosa (RP), carry a mutation of Rhodopsin gene that can be activated by brief exposure to very intense light. Here, we test the possibility of an anatomical,… read more here.
Keywords: myriocin effect; autosomal dominant; myriocin; retinitis pigmentosa ... See more keywords