Exploring Subsite Selectivity within Plasmodium vivaxN-Myristoyltransferase Using Pyrazole-Derived Inhibitors
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.4c00168
Abstract: N-myristoyltransferase (NMT) is a promising antimalarial drug target. Despite biochemical similarities between Plasmodium vivax and human NMTs, our recent research demonstrated that high selectivity is achievable. Herein, we report PvNMT-inhibiting compounds aimed at identifying novel… read more here.
Keywords: exploring subsite; subsite selectivity; selectivity within; myristoyltransferase ... See more keywords
Inhibition of human N myristoyltransferase 1 as a strategy to suppress cancer progression driven by myristoylation
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-13529-8
Abstract: N-myristoyltransferase 1 (NMT-1) catalyzes the co-translational addition of myristic acid to the N-terminal glycine of substrate proteins, regulating membrane localization and protein-protein interactions essential for oncogenic signaling. Its overexpression in diverse malignancies has rendered NMT-1… read more here.
Keywords: 289 547; human myristoyltransferase; myristoyltransferase; myristoyltransferase strategy ... See more keywords
N-Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04212-22
Abstract: As an opportunistic pathogen, A. flavus causes crop loss due to fungal growth and mycotoxin contamination. Investigating the role of virulence factors during infection and searching for novel drug targets have been popular scientific topics… read more here.
Keywords: flavus; role; myristoyltransferase; drug ... See more keywords
Abstract 7381: Mathematical modeling and validation of mechanistic target of rapamycin and N-myristoyltransferase signaling pathways in breast cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7381
Abstract: Hormone receptor-positive (HR+) breast cancer (BC) makes up approximately 65% of all breast cancers diagnosed. The prognosis for early-stage disease is excellent with mainstay endocrine therapy (ET). Despite the effectiveness of standard ET, as many… read more here.
Keywords: breast cancer; cancer; insulin; myristoyltransferase ... See more keywords