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   Articles with "mysm1" as a keyword



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Deubiquitinase Mysm1 regulates macrophage survival and polarization

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recommendations! Published in 2018 at "Molecular Biology Reports"

DOI: 10.1007/s11033-018-4405-3

Abstract: Macrophages play pivotal roles in innate and adaptive immune response, tissue homeostasis and cancer development. Their development and heterogeneity are tightly controlled by epigenetic program and transcription factors. Deubiquitinase Mysm1 plays crucial roles in regulating… read more here.

Keywords: deubiquitinase mysm1; mysm1 macrophages; mysm1; polarization ... See more keywords
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Mysm1 expression in the bone marrow niche is not essential for hematopoietic maintenance.

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recommendations! Published in 2017 at "Experimental hematology"

DOI: 10.1016/j.exphem.2016.10.013

Abstract: Myb-Like SWIRM and MPN domains 1 (MYSM1) is a chromatin-binding protein, essential for hematopoietic stem cell (HSC) maintenance and differentiation in humans and mouse models. HSCs in mammalian bone marrow exist in close interactions with… read more here.

Keywords: mysm1; maintenance; bone; niche ... See more keywords
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MYSM1 induces apoptosis and sensitizes TNBC cells to cisplatin via RSK3–phospho-BAD pathway

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recommendations! Published in 2022 at "Cell Death Discovery"

DOI: 10.1038/s41420-022-00881-1

Abstract: Breast cancer is one of the leading causes of mortality among women. Triple-negative breast cancer (TNBC) is responsible for a large percentage of all breast cancer deaths in women. This study demonstrated the function of… read more here.

Keywords: apoptosis; breast cancer; tnbc; mysm1 ... See more keywords
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Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma

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recommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.16554

Abstract: MYSM1 is a chromatin‐binding protein, widely investigated for its functions in haematopoiesis in human and mouse; however, its role in haematologic malignancies remains unexplored. Here, we investigate the cross‐talk between MYSM1 and oncogenic cMYC in… read more here.

Keywords: mysm1; cmyc; loss mysm1; cell lymphoma ... See more keywords