Myxochelin‐Inspired 5‐Lipoxygenase Inhibitors: Synthesis and Biological Evaluation
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DOI: 10.1002/cmdc.201600536
Abstract: A total of 48 analogues of the natural product myxochelin A were prepared and evaluated for their inhibitory effects on human 5‐lipoxygenase in both cell‐free and cell‐based assays. Structure–activity relationship analysis revealed that the secondary alcohol… read more here.
Keywords: inhibitors synthesis; myxochelin inspired; inspired lipoxygenase; myxochelin ... See more keywords