Myxoma virus jumps species to the Iberian hare.
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DOI: 10.1111/tbed.13296
Abstract: The study of myxoma virus (MYXV) infections in the European rabbit (Oryctolagus cuniculus) has produced one of the most accepted host-pathogen evolutionary models. To date myxomatosis has been limited to the European rabbit with sporadic… read more here.
Keywords: iberian hare; hare; european rabbit; myxoma virus ... See more keywords
Recombinant myxoma virus infection associated with high mortality in rabbit farming (Oryctolagus cuniculus).
Sign Up to like & getrecommendations! Published in 2020 at "Transboundary and emerging diseases"
DOI: 10.1111/tbed.13899
Abstract: Myxomatosis is an emergent disease in the Iberian hare, having been considered a rabbit disease for decades. Genome sequencing of the strains obtained from Iberian hares with myxomatosis showed these to be distinct from the… read more here.
Keywords: associated high; oryctolagus cuniculus; rabbit; myxoma virus ... See more keywords
Parallel adaptation of rabbit populations to myxoma virus
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aau7285
Abstract: Locating myxomatosis resistance Myxomatosis is a viral infection that was deliberately introduced from American cottontail rabbits into European rabbit populations to control their population. Over the past 60 years or so, similar resistance variants have… read more here.
Keywords: rabbit populations; european rabbit; resistance; rabbit ... See more keywords
Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication
Sign Up to like & getrecommendations! Published in 2020 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-000804
Abstract: Background Oncolytic therapy uses live-replicating viruses to improve the immunological status of treated tumors. Critically, while these viruses are known to self-amplify in vivo, clinical oncolytic therapies still appear to display a strong dose dependence… read more here.
Keywords: initial dose; oncolytic myxoma; myxoma virus; treated tumors ... See more keywords
TNF blockade enhances the efficacy of myxoma virus-based oncolytic virotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004770
Abstract: Background Oncolytic virotherapy (OV) represents a method to treat a variety of solid tumors by inducing antitumor immune responses. While this therapy has been extremely efficacious in preclinical models, translating these successes into human patients… read more here.
Keywords: tnf; efficacy; blockade; myxoma virus ... See more keywords
Abstract PO091: Armed Myxoma virus demonstrates efficacy in syngeneic tumor models alone and in combination with immune checkpoint inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer immunology research"
DOI: 10.1158/2326-6074.tumimm20-po091
Abstract: Oncolytic Viruses (OV) selectively replicate in and lyse tumor cells and provide stimulation to the immune system. This represents a promising therapeutic option for cancer patients that do not respond well to treatment with immune… read more here.
Keywords: immune checkpoint; myxoma virus; immunology; tumor ... See more keywords
Transplantation of autologous bone marrow pre-loaded ex vivo with oncolytic myxoma virus is efficacious against drug-resistant Vk*MYC mouse myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Oncotarget"
DOI: 10.18632/oncotarget.28205
Abstract: Multiple myeloma (MM) is a hematological malignancy of plasma cells that remains incurable despite significant progress with myeloablative regimens and autologous stem cell transplantation for eligible patients and, more recently with T cell redirected immunotherapy.… read more here.
Keywords: myxv; myxoma virus; autologous bone; oncolytic myxoma ... See more keywords
A Quadruplex qPCR for Detection and Differentiation of Classic and Natural Recombinant Myxoma Virus Strains of Leporids
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222112052
Abstract: A natural recombinant myxoma virus (referred to as ha-MYXV or MYXV-Tol08/18) emerged in the Iberian hare (Lepus granatensis) and the European rabbit (Oryctolagus cuniculus) in late 2018 and mid-2020, respectively. This new virus is genetically… read more here.
Keywords: myxv strains; recombinant; myxoma virus; myxv ... See more keywords
Evaluation of Commercial Myxomatosis Vaccines against Recombinant Myxoma Virus (ha-MYXV) in Iberian Hare and Wild Rabbit
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DOI: 10.3390/vaccines10030356
Abstract: The recent emergence of a new myxoma virus capable of causing disease in the Iberian hare (Lepus granatensis) has resulted in numerous outbreaks with high mortality leading to the reduction, or even the disappearance, of… read more here.
Keywords: vaccine; iberian hare; myxoma virus; myxv ... See more keywords
Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways
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DOI: 10.3390/vaccines8020244
Abstract: Myxoma virus (MYXV) is the prototypic member of the Leporipoxvirus genus of the Poxviridae family of viruses. In nature, MYXV is highly restricted to leporids and causes a lethal disease called myxomatosis only in European… read more here.
Keywords: host antiviral; antiviral innate; host; myxoma virus ... See more keywords