Reconstitution of Microtubule Nucleation In Vitro Reveals Novel Roles for Mzt1
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.05.058
Abstract: Summary Microtubule (MT) nucleation depends on the γ-tubulin complex (γ-TuC), in which multiple copies of the heterotetrameric γ-tubulin small complex (γ-TuSC) associate to form a ring-like structure (in metazoans, γ-tubulin ring complex; γ-TuRC) [1, 2,… read more here.
Keywords: microtubule nucleation; microtubule; mzt1; reconstitution ... See more keywords
MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.195321
Abstract: ABSTRACT Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding in the assembly of ordered microtubule arrays. However, the mechanistic basis of this important… read more here.
Keywords: turc assembly; mzt1; targeting activation; nucleation ... See more keywords