Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors.
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DOI: 10.1021/acsinfecdis.8b00275
Abstract: Bacterial tRNA modification synthesis pathways are critical to cell survival under stress and thus represent ideal mechanism-based targets for antibiotic development. One such target is the tRNA-(N1G37) methyltransferase (TrmD), which is conserved and essential in… read more here.
Keywords: trmd; n1g37 methyltransferase; trna n1g37; antibiotic development ... See more keywords