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   Articles with "n2a cells" as a keyword



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Minocycline Promotes BDNF Expression of N2a Cells via Inhibition of miR-155-Mediated Repression After Oxygen-Glucose Deprivation and Reoxygenation

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recommendations! Published in 2018 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-018-0599-0

Abstract: Minocycline, an anti-infective agent of a tetracycline derivative, is reported to improve behavioral functional recovery after cerebral ischemia via enhancing the levels of brain-derived neurotrophic factor (BDNF). However, the precise mechanisms that minocycline targets to… read more here.

Keywords: minocycline; mir 155; expression; oxygen glucose ... See more keywords
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Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro

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recommendations! Published in 2018 at "Experimental Gerontology"

DOI: 10.1016/j.exger.2018.04.005

Abstract: ABSTRACT Changes in mitochondrial structure and function are the initial factors of cell aging. Spermidine has an antiaging effect, but its effect on neuronal aging and mitochondrial mechanisms is unclear. In this study, mouse neuroblastoma… read more here.

Keywords: cell aging; gal treatment; spermidine; n2a cells ... See more keywords
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MiR-202-5p attenuates neurological deficits and neuronal injury in MCAO model rats and OGD-induced injury in Neuro-2a cells by targeting eIF4E-mediated induction of autophagy and inhibition of Akt/GSK-3β pathway.

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recommendations! Published in 2019 at "Molecular and cellular probes"

DOI: 10.1016/j.mcp.2019.101497

Abstract: Ischemic stroke is a common cerebrovascular disease caused by insufficient blood supply to the brain. In recent years, studies have demonstrated that microRNAs (miRNAs) are involved in a variety of biological processes in the nervous… read more here.

Keywords: ogd induced; induced injury; n2a cells; mcao ... See more keywords
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Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells.

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recommendations! Published in 2022 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.1c00591

Abstract: Alzheimer's disease (AD) is the most common type of dementia that occurs in the elderly. Amyloid hypothesis is one of the most studied pathological mechanisms, and β-amyloid (Aβ) is the drug target for most clinical… read more here.

Keywords: myricetin restores; induced mitochondrial; n2a cells; restores induced ... See more keywords
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Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer’s disease

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recommendations! Published in 2017 at "Cell Death Discovery"

DOI: 10.1038/cddiscovery.2017.7

Abstract: Malathion is an organophosphate with severe neurotoxic effects. Upon acute exposure, malathion initially enhances cholinergic activity by inhibition of acetylcholinesterase, which is its major pathological mechanism. Malathion also induces non-cholinergic neuronal cell death in neurodegenerative… read more here.

Keywords: cell death; malathion; n2a cells; cell ... See more keywords
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Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity

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recommendations! Published in 2019 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddy335

Abstract: Abstract The purpose of our study was to better understand the effects of mitochondrial-division inhibitor 1 (Mdivi-1) on mitochondrial fission, mitochondrial biogenesis, electron transport activities and cellular protection. In recent years, researchers have found excessive… read more here.

Keywords: fission; n2a cells; mitochondrial fission; mitochondrial division ... See more keywords
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Entry of Challenge Virus Standard (CVS) -11 into N2a cells via a clathrin-mediated, cholesterol-, dynamin-, pH-dependent endocytic pathway

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recommendations! Published in 2019 at "Virology Journal"

DOI: 10.1186/s12985-019-1186-9

Abstract: BackgroundRabies virus (RABV), a member of Lyssavirus of Rhabdoviridae family, is a kind of negative-strand RNA virus. The zoonosis caused by RABV leads to high mortality in animals and humans. Though with the extensive investigation,… read more here.

Keywords: cvs; microscopy; cholesterol; n2a cells ... See more keywords

DDX3X Deficiency attenuates Pyroptosis Induced by Oxygen-Glucose Deprivation/Reoxygenation in N2a Cells.

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recommendations! Published in 2023 at "Current neurovascular research"

DOI: 10.2174/1567202620666230522155944

Abstract: BACKGROUND NOD‑like receptor protein 3 (NLRP3) inflammasome-mediated pyroptosis is strongly related to cerebral ischemia/reperfusion (I/R) injury. DDX3X, the DEAD-box family's ATPase/RNA helicase, promotes NLRP3 inflammasome activation. However, whether DDX3X deficiency attenuates NLRP3 inflammasome-mediated pyroptosis induced… read more here.

Keywords: pyroptosis; nlrp3 inflammasome; n2a cells; ddx3x deficiency ... See more keywords