Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.
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DOI: 10.1093/hmg/ddac038
Abstract: Cognitive impairment is a common non-motor complication of Parkinson disease (PD). Glucocerebrosidase gene (GBA1) variants are found in 10-15% of PD cases and are numerically the most important risk factor for PD and dementia with… read more here.
Keywords: synuclein tau; n370s gba1; cholinergic neurons; gba1 mutation ... See more keywords