Construction of a mutant of Actinoplanes sp. N902-109 that produces a new rapamycin analog.
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DOI: 10.1016/s1875-5364(18)30049-9
Abstract: In the present study, we introduced point mutations into Ac_rapA which encodes a polyketide synthase responsible for rapamycin biosynthesis in Actinoplanes sp. N902-109, in order to construct a mutant with an inactivated enoylreductase (ER) domain,… read more here.
Keywords: n902 109; actinoplanes n902; rapamycin analog; mutant ... See more keywords