NAADP‐induced intracellular calcium ion is mediated by the TPCs (two‐pore channels) in hypoxia‐induced pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16783
Abstract: Pulmonary arterial hypertension (PAH) is a form of obstructive vascular disease. Chronic hypoxic exposure leads to excessive proliferation of pulmonary arterial smooth muscle cells and pulmonary arterial endothelial cells. This condition can potentially be aggravated… read more here.
Keywords: tpc1; arterial hypertension; naadp induced; pulmonary arterial ... See more keywords
Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells
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DOI: 10.3389/fcell.2022.874043
Abstract: Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca2+ release. NAADP-induced lysosomal Ca2+ release may be amplified… read more here.
Keywords: ca2 release; naadp induced; ca2; proliferation ... See more keywords