Electrostatic Intraperitoneal Aerosol Delivery of Nanoparticles: Proof of Concept and Preclinical Validation.
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DOI: 10.1002/adhm.202000655
Abstract: There is an increasing interest in intraperitoneal delivery of chemotherapy as an aerosol in patients with peritoneal metastasis. The currently used technology is hampered by inhomogenous drug delivery throughout the peritoneal cavity because of gravity,… read more here.
Keywords: nab ptx; intraperitoneal; delivery; tissue ... See more keywords
A clinical trial to assess the feasibility and efficacy of nab-paclitaxel plus gemcitabine for elderly patients with unresectable advanced pancreatic cancer
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DOI: 10.1007/s10147-019-01511-0
Abstract: The efficacy and safety of nanoparticle albumin-bound paclitaxel (nab-PTX) plus gemcitabine (GEM) in elderly Japanese patients with pancreatic cancer remain unclear. Therefore, we prospectively investigated the tolerability and efficacy of nab-PTX + GEM in Japanese patients aged… read more here.
Keywords: nab ptx; pancreatic cancer; efficacy; plus gemcitabine ... See more keywords
Nab-paclitaxel maintenance therapy following carboplatin + nab-paclitaxel combination therapy in chemotherapy naïve patients with advanced non-small cell lung cancer: multicenter, open-label, single-arm phase II trial
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DOI: 10.1007/s10637-018-0617-6
Abstract: SummaryBackground A global multicenter study demonstrated superiority of carboplatin + nab-paclitaxel (PTX) therapy compared to carboplatin + PTX in terms of response rate (RR) and non-inferiority in terms of progression free survival (PFS) and overall… read more here.
Keywords: nab ptx; nab paclitaxel; maintenance therapy; maintenance ... See more keywords
Efficacy and safety of nanoparticle albumin-bound paclitaxel monotherapy as second-line therapy of cytotoxic anticancer drugs in patients with advanced non-small cell lung cancer
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DOI: 10.1097/md.0000000000009320
Abstract: Background: Nanoparticle albumin-bound paclitaxel (nab-PTX), which avoids toxicities associated with a vehicle used in solvent-based PTX, has already shown safety and efficacy in patients with non-small cell lung cancer (NSCLC). Methods: A phase II study… read more here.
Keywords: nab ptx; cytotoxic anticancer; safety; efficacy ... See more keywords
Weekly nanoparticle albumin-bound paclitaxel and paclitaxel for relapsed small cell lung cancer
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DOI: 10.1097/md.0000000000028863
Abstract: Abstract In addition to advanced non-small cell lung cancer, nanoparticle albumin-bound paclitaxel (nab-PTX) may also harbor potential benefit for patients with relapsed small cell lung cancer (SCLC), since weekly paclitaxel (PTX) shows modest activity for… read more here.
Keywords: lung cancer; ptx; small cell; paclitaxel ... See more keywords
A randomized controlled study of a combination of internal and external treatments for albumin paclitaxel-related peripheral neurotoxicity: A randomized controlled: A study protocol
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DOI: 10.1097/md.0000000000032252
Abstract: Introduction: Albumin-bound paclitaxel (nab-PTX), a novel paclitaxel preparation, has been found to successfully blocks tumor progression in breast and lung cancer. However, at the same time of as clinical application, neurotoxicity caused by nab-PTX has… read more here.
Keywords: randomized controlled; peripheral neurotoxicity; controlled study; neurotoxicity ... See more keywords
Results of a Phase II Study on the Use of Neoadjuvant Chemotherapy (FOLFIRINOX or GEM/nab-PTX) for Borderline-resectable Pancreatic Cancer (NUPAT-01)
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DOI: 10.1097/sla.0000000000005430
Abstract: Objective: Given the frequent adverse events with multidrug chemotherapy, not only the survival benefit but also the feasibility of using neoadjuvant chemotherapy to treat pancreatic cancer need to be clarified. Summary of Background Data: Although… read more here.
Keywords: neoadjuvant chemotherapy; pancreatic cancer; gem nab; chemotherapy ... See more keywords
Abstract P2-16-13: Meta-analysis of nanoparticle albumin-bound paclitaxel (Nab-PTX) used as a neoadjuvant chemotherapy for operable breast cancer based on individual patient data (JBCRG-S01)
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DOI: 10.1158/1538-7445.sabcs19-p2-16-13
Abstract: [Background] Nanoparticle albumin-bound paclitaxel (Nab-PTX) is a novel taxane formulation that was developed to avoid Cremophor/ethanol associated toxicities such as peripheral neuropathy and hypersensitive reactions. Since Taxol plays an important role in breast cancer therapy,… read more here.
Keywords: nab ptx; ptx; breast cancer;
Multicenter, single-arm phase II study of modified carboplatin/nab-paclitaxel in untreated performance status 2 patients with advanced non-small cell lung cancer: TORG1426
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DOI: 10.21037/tcr-22-2144
Abstract: Background Currently, only a few treatment options exist for performance status (PS) 2 patients with advanced non-small cell lung cancer (NSCLC), whereas the carboplatin/nab-paclitaxel (CBDCA/nab-PTX) regimen is attracting attention as a standard of care for… read more here.
Keywords: patients advanced; performance status; status patients; advanced non ... See more keywords
A multi-center, Phase II trial of nab-paclitaxel and gemcitabine in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy
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DOI: 10.2147/cmar.s208224
Abstract: Background Nanoparticle albumin-bound paclitaxel (nab-PTX) plus gemcitabine (GEM) significantly improved overall survival in patients with metastatic pancreatic adenocarcinoma. Anti-tumor synergy between GEM and nab-PTX was recently demonstrated in a mouse model. We planned to assess… read more here.
Keywords: based chemotherapy; nab ptx; cell; platinum based ... See more keywords
Clinical Characteristics and Risk Factors of Lung Injury Induced by Nab-Paclitaxel
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DOI: 10.2147/dddt.s342283
Abstract: Background/Aim Nab-paclitaxel (Nab-PTX) has been widely used to treat several advanced cancers. Nab-PTX can cause drug-induced lung injury (DILI); however, its clinical and radiographic features have not been clarified. We aimed to assess the clinical… read more here.
Keywords: injury; nab ptx; risk factors; lung injury ... See more keywords