The binding orientations of structurally-related ligands can differ; A cautionary note
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DOI: 10.1016/j.neuropharm.2017.01.023
Abstract: ABSTRACT Crystal structures can identify ligand‐receptor interactions and assist the development of novel therapeutics, but experimental challenges sometimes necessitate the use of homologous proteins. Tropisetron is an orthosteric ligand at both 5‐HT3 and &agr;7 nACh… read more here.
Keywords: binding orientations; nach receptors; agr nach; structurally related ... See more keywords