&agr;-Ketoglutarate drives electroneutral NaCl reabsorption in intercalated cells by activating a G-protein coupled receptor, Oxgr1
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000353
Abstract: Purpose of review This review describes the recent discoveries about a powerful electroneutral NaCl reabsorption mechanism in intercalated cells, and its regulation by an intrarenal metabolite paracrine, &agr;-ketoglutartate, and the G-protein coupled receptor, Oxgr1. Recent… read more here.
Keywords: protein; electroneutral nacl; reabsorption; intercalated cells ... See more keywords
Nephron-specific deletion of ALMS1 (Alstrom syndrome 1) increases surface NKCC2 expression and NaCl reabsorption in the Thick Ascending Limb
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731922
Abstract: Mutations in the ALMS1 gene in humans cause Alström syndrome, characterized by progressive metabolic alterations that include obesity, hypertension, and chronic kidney disease (CKD). SNPs in the ALMS1 gene in the general population are associated… read more here.
Keywords: deletion; pax8 alms1; expression; physiology ... See more keywords
Slc4a11 disruption causes duct cell loss and impairs NaCl reabsorption in female mouse submandibular glands
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DOI: 10.14814/phy2.14232
Abstract: Slc4a11, a member of the Slc4 HCO3− transporter family, has a wide tissue distribution. In mouse salivary glands, the expression of Slc4a11 mRNA was more than eightfold greater than the other nine members of the… read more here.
Keywords: nacl reabsorption; duct; slc4a11 disruption; mouse ... See more keywords