Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113219
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD+ availability, or increasing the expression of the NAD+-dependent deacylases SIRT3… read more here.
Keywords: mouse models; effect; nad levels; nad ... See more keywords
Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120571
Abstract: Mitochondrial complex I (CI), the first multiprotein enzyme complex of the oxidative phosphorylation system, plays a crucial role in cellular energy production. CI deficiency is associated with a variety of clinical phenotypes, including Leigh syndrome.… read more here.
Keywords: deficiency; nad levels; nad; cellular nad ... See more keywords
Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD+ Analogue.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05852
Abstract: The synthesis, photophysics, and biochemical utility of a fluorescent NAD+ analogue based on an isothiazolo[4,3-d]pyrimidine core (NtzAD+) are described. Enzymatic reactions, photophysically monitored in real time, show NtzAD+ and NtzADH to be substrates for yeast… read more here.
Keywords: cofactors isomorphic; synthetic cofactors; emissive synthetic; analogue ... See more keywords
Keeping the balance in NAD metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society transactions"
DOI: 10.1042/bst20180417
Abstract: Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of… read more here.
Keywords: balance nad; keeping balance; nad; nad levels ... See more keywords
Dunnione protects against experimental cisplatin-induced nephrotoxicity by modulating NQO1 and NAD+ levels
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Research"
DOI: 10.1080/10715762.2018.1475732
Abstract: Abstract Despite being an efficacious anticancer agent, the clinical utility of cisplatin is hindered by its cardinal side effects. This investigation aimed to appraise potential protective impact of dunnione, a natural naphthoquinone pigment with established… read more here.
Keywords: induced nephrotoxicity; cisplatin; nad; cisplatin induced ... See more keywords
ONE-seq: epitranscriptome and gene-specific profiling of NAD-capped RNA
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1136
Abstract: Abstract The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating nucleotide in RNA synthesis to result in NAD-capped RNAs (NAD-RNA). Since NAD has been heightened as one of the most essential… read more here.
Keywords: nad capped; nad; epitranscriptome gene; one seq ... See more keywords
Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases
Sign Up to like & getrecommendations! Published in 2020 at "Acta Physiologica"
DOI: 10.1111/apha.13551
Abstract: Nicotinamide adenine dinucleotide (NAD) is an abundant cofactor that plays crucial roles in several cellular processes. NAD can be synthesized de novo starting with tryptophan, or from salvage pathways starting with NAD precursors like nicotinic… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; nad; dinucleotide biosynthesis ... See more keywords
Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Cell Physiology"
DOI: 10.1152/ajpcell.00239.2022
Abstract: Nicotinamide adenine dinucleotide (NAD+) is a critical redox factor and coenzyme with rhythmic availability, and reduced NAD+ levels are a common factor of many disease states, including risk factors associated with aging. Recent studies have… read more here.
Keywords: nad; nad metabolism; physiology; regulation ... See more keywords
Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors
Sign Up to like & getrecommendations! Published in 2021 at "Aging and Disease"
DOI: 10.14336/ad.2021.0523
Abstract: Coenzyme I (nicotinamide adenine dinucleotide, NAD+/NADH) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP+/NADPH) are involved in various biological processes in mammalian cells. NAD+ is synthesised through the de novo and salvage pathways, whereas coenzyme… read more here.
Keywords: pharmacology potential; nad; coenzyme; pharmacology ... See more keywords
Association of NAD+ levels with metabolic disease in a community-based study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1164788
Abstract: Background Nicotinamide adenine dinucleotide (NAD+) is a coenzyme and plays a crucial role in several metabolic processes. This study explored the association of nicotinamide adenine dinucleotide (NAD+) levels with metabolic disease (MD) in adults. Methods… read more here.
Keywords: nad; metabolic disease; levels metabolic; association ... See more keywords
Altered Expression of Mitochondrial NAD+ Carriers Influences Yeast Chronological Lifespan by Modulating Cytosolic and Mitochondrial Metabolism
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00676
Abstract: Nicotinamide adenine dinucleotide (NAD+) represents an essential cofactor in sustaining cellular bioenergetics and maintaining cellular fitness, and has emerged as a therapeutic target to counteract aging and age-related diseases. Besides NAD+ involvement in multiple redox… read more here.
Keywords: mitochondrial nad; metabolism; nad carriers; nad ... See more keywords