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   Articles with "nad" as a keyword



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Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models

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recommendations! Published in 2020 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2020.113219

Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD+ availability, or increasing the expression of the NAD+-dependent deacylases SIRT3… read more here.

Keywords: mouse models; effect; nad levels; nad ... See more keywords
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Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency.

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recommendations! Published in 2022 at "Life sciences"

DOI: 10.1016/j.lfs.2022.120571

Abstract: Mitochondrial complex I (CI), the first multiprotein enzyme complex of the oxidative phosphorylation system, plays a crucial role in cellular energy production. CI deficiency is associated with a variety of clinical phenotypes, including Leigh syndrome.… read more here.

Keywords: deficiency; nad levels; nad; cellular nad ... See more keywords
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Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD+ Analogue.

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recommendations! Published in 2017 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b05852

Abstract: The synthesis, photophysics, and biochemical utility of a fluorescent NAD+ analogue based on an isothiazolo[4,3-d]pyrimidine core (NtzAD+) are described. Enzymatic reactions, photophysically monitored in real time, show NtzAD+ and NtzADH to be substrates for yeast… read more here.

Keywords: cofactors isomorphic; synthetic cofactors; emissive synthetic; analogue ... See more keywords

NMNAT2 is a druggable target to drive neuronal NAD production

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-50354-5

Abstract: Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to neurodegenerative… read more here.

Keywords: drive neuronal; neuronal nad; nad production; nmnat2 druggable ... See more keywords

Catalytic reduction of NAD(P)+ to NAD(P)H.

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recommendations! Published in 2025 at "Chemical communications"

DOI: 10.1039/d4cc06254j

Abstract: 1,4-Dihydronicotinamide adenine dinucleotide (NADH) and its phosphate ester (NADPH) are essential cofactors required for all living cells, playing pivotal roles in multiple biological processes such as energy metabolism and biosynthesis. NADPH is produced during photosynthesis… read more here.

Keywords: nad nad; reduction nad; photosystem model; reduction ... See more keywords

Keeping the balance in NAD metabolism.

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recommendations! Published in 2019 at "Biochemical Society transactions"

DOI: 10.1042/bst20180417

Abstract: Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of… read more here.

Keywords: balance nad; keeping balance; nad; nad levels ... See more keywords

Dunnione protects against experimental cisplatin-induced nephrotoxicity by modulating NQO1 and NAD+ levels

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recommendations! Published in 2018 at "Free Radical Research"

DOI: 10.1080/10715762.2018.1475732

Abstract: Abstract Despite being an efficacious anticancer agent, the clinical utility of cisplatin is hindered by its cardinal side effects. This investigation aimed to appraise potential protective impact of dunnione, a natural naphthoquinone pigment with established… read more here.

Keywords: induced nephrotoxicity; cisplatin; nad; cisplatin induced ... See more keywords

ONE-seq: epitranscriptome and gene-specific profiling of NAD-capped RNA

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1136

Abstract: Abstract The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating nucleotide in RNA synthesis to result in NAD-capped RNAs (NAD-RNA). Since NAD has been heightened as one of the most essential… read more here.

Keywords: nad capped; nad; epitranscriptome gene; one seq ... See more keywords

Nicotinamide adenine dinucleotide: Biosynthesis, consumption and therapeutic role in cardiac diseases

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recommendations! Published in 2020 at "Acta Physiologica"

DOI: 10.1111/apha.13551

Abstract: Nicotinamide adenine dinucleotide (NAD) is an abundant cofactor that plays crucial roles in several cellular processes. NAD can be synthesized de novo starting with tryptophan, or from salvage pathways starting with NAD precursors like nicotinic… read more here.

Keywords: adenine dinucleotide; nicotinamide adenine; nad; dinucleotide biosynthesis ... See more keywords

Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging

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recommendations! Published in 2022 at "American Journal of Physiology - Cell Physiology"

DOI: 10.1152/ajpcell.00239.2022

Abstract: Nicotinamide adenine dinucleotide (NAD+) is a critical redox factor and coenzyme with rhythmic availability, and reduced NAD+ levels are a common factor of many disease states, including risk factors associated with aging. Recent studies have… read more here.

Keywords: nad; nad metabolism; physiology; regulation ... See more keywords

Mitochondrial NAD Profile in a Rat Model of Attention-Deficit/Hyperactivity Disorder

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recommendations! Published in 2024 at "Physiology"

DOI: 10.1152/physiol.2024.39.s1.946

Abstract: Mitochondria require nicotinamide adenine dinucleotide (NAD) to satisfy cellular energy needs. Mitochondrial stress has been reported in skeletal muscle tissue of humans with attention-deficit/hyperactivity disorder. NAD deficiency may indicate mitochondrial stress that can be assessed… read more here.

Keywords: physiology; sprague dawley; attention deficit; nad ... See more keywords