Emissive Synthetic Cofactors: An Isomorphic, Isofunctional, and Responsive NAD+ Analogue.
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DOI: 10.1021/jacs.7b05852
Abstract: The synthesis, photophysics, and biochemical utility of a fluorescent NAD+ analogue based on an isothiazolo[4,3-d]pyrimidine core (NtzAD+) are described. Enzymatic reactions, photophysically monitored in real time, show NtzAD+ and NtzADH to be substrates for yeast… read more here.
Keywords: cofactors isomorphic; synthetic cofactors; emissive synthetic; analogue ... See more keywords
Discovery of an NAD+ analogue with enhanced specificity for PARP1
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DOI: 10.1039/d1sc06256e
Abstract: Among various protein posttranslational modifiers, poly-ADP-ribose polymerase 1 (PARP1) is a key player for regulating numerous cellular processes and events through enzymatic attachments of target proteins with ADP-ribose units donated by nicotinamide adenine dinucleotide (NAD+).… read more here.
Keywords: discovery nad; parp1; nad analogue; specificity ... See more keywords