Hyperglycemia-reduced NAD+ biosynthesis impairs corneal epithelial wound healing in diabetic mice.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154402
Abstract: OBJECTIVE Nicotinamide adenine dinucleotide (NAD) is an essential molecule participating in multiple physiological and pathophysiological processes. In diabetic cornea, the NAD+-consuming enzyme SIRT1 was down-regulated and contributed to the delayed wound healing. However, the impact… read more here.
Keywords: wound healing; epithelial wound; corneal epithelial; nad biosynthesis ... See more keywords
NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220102120
Abstract: Significance We evaluate the role of NAD+ circadian control by comparing diurnal gene expression across brown adipose tissue (BAT), white adipose tissue (WAT), and skeletal muscle of mice with tissue-specific deletion of the NAD+ biosynthetic… read more here.
Keywords: nad biosynthesis; tissue specific; tissue; nampt dependent ... See more keywords
Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.954512
Abstract: Cancer cells are known to undergo metabolic adaptation to cater to their enhanced energy demand. Nicotinamide adenine dinucleotide (NAD) is an essential metabolite regulating many cellular processes within the cell. The enzymes required for NAD… read more here.
Keywords: personalized quantitative; poor prognosis; nad biosynthesis; nad biosynthetic ... See more keywords
Nicotinaldehyde, a Novel Precursor of NAD Biosynthesis, Abrogates the Anti-Cancer Activity of an NAD-Lowering Agent in Leukemia
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DOI: 10.3390/cancers15030787
Abstract: Simple Summary Cancer cells are reliant on a sufficient amount of nicotinamide adenine nucleotide (NAD) to sustain their altered metabolism and proliferation. Targeting NAD depletion with inhibitors of NAD biosynthesis has therefore emerged as a… read more here.
Keywords: biosynthesis; anti cancer; leukemia; nad biosynthesis ... See more keywords