NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.030
Abstract: HIGHLIGHTSFirst investigation of the role of NMNAT1 in the early stage of tauopathies in mice.htau mice display a robust deficit in food burrowing prior to onset of cognitive symptoms.NMNAT1 overexpression rescues this behavioral abnormality. ABSTRACT… read more here.
Keywords: nad biosynthetic; htau mice; model tauopathy; nmnat1 ... See more keywords
Small Molecule Regulators Targeting NAD+ Biosynthetic Enzymes.
Sign Up to like & getrecommendations! Published in 2021 at "Current medicinal chemistry"
DOI: 10.2174/0929867328666210531144629
Abstract: Nicotinamide adenine dinucleotide (NAD+) is a key player in many metabolic pathways as an activated carrier of electrons. In addition to being the cofactor for redox reactions, NAD+ also serves as the substrate for various… read more here.
Keywords: nad biosynthetic; molecule regulators; small molecule; targeting nad ... See more keywords
Personalized quantitative models of NAD metabolism in hepatocellular carcinoma identify a subgroup with poor prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.954512
Abstract: Cancer cells are known to undergo metabolic adaptation to cater to their enhanced energy demand. Nicotinamide adenine dinucleotide (NAD) is an essential metabolite regulating many cellular processes within the cell. The enzymes required for NAD… read more here.
Keywords: personalized quantitative; poor prognosis; nad biosynthesis; nad biosynthetic ... See more keywords