NAD+ Cleavage: TIR Domain-Containing Resistance Proteins in Action.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in plant science"
DOI: 10.1016/j.tplants.2019.10.005
Abstract: Plant resistance proteins play a key role in detecting pathogen infection and activating plant defense. Two recent papers by Horsefield et al. and Wan et al. revealed that the TIR domain in resistance (R) proteins functions as an NAD+-cleaving… read more here.
Keywords: tir domain; resistance proteins; resistance; nad cleavage ... See more keywords
Carnosol, a Rosemary Ingredient Discovered in a Screen for Inhibitors of SARM1-NAD+ Cleavage Activity, Ameliorates Symptoms of Peripheral Neuropathy
Sign Up to like & getrecommendations! Published in 2025 at "Antioxidants"
DOI: 10.3390/antiox14070808
Abstract: Sterile alpha and Toll/interleukin receptor motif-containing protein 1 (SARM1) is a nicotinamide adenine dinucleotide (NAD+) hydrolase involved in axonal degeneration and neuronal cell death. SARM1 plays a pivotal role in triggering the neurodegenerative processes that… read more here.
Keywords: sarm1; cleavage activity; nad cleavage; carnosol ... See more keywords