Mechanistic Insight into the Catalytic Promiscuity of Amine Dehydrogenases: Asymmetric Synthesis of Secondary and Primary Amines
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201800626
Abstract: Biocatalytic asymmetric amination of ketones, by using amine dehydrogenases (AmDHs) or transaminases, is an efficient method for the synthesis of α‐chiral primary amines. A major challenge is to extend amination to the synthesis of secondary… read more here.
Keywords: primary amines; synthesis secondary; nad dependent; secondary amines ... See more keywords
NAD(P)‐Dependent Glucose Dehydrogenases: Underestimated Multifunctional Biocatalysts
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202400716
Abstract: The last decade has witnessed tremendous progress in the field of biocatalysis. One of the most frequently utilized enzymes in diverse biocatalytic applications is NAD(P)‐dependent glucose dehydrogenases (GDHs). Traditionally, these enzymes are employed for their… read more here.
Keywords: underestimated multifunctional; nad dependent; glucose dehydrogenases; dependent glucose ... See more keywords
NAD(P)‐dependent steroid dehydrogenase‐like protein and neutral cholesterol ester hydrolase 1 serve as novel markers for early detection of gastric cancer identified using quantitative proteomics
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23652
Abstract: Gastric cancer (GC) is the third most common cause of cancer deaths worldwide. In the present study, we aimed to identify novel GC biomarkers by integrating isobaric tags of relative and absolute quantitation (iTRAQ) for… read more here.
Keywords: dependent steroid; nad dependent; gastric cancer; dehydrogenase like ... See more keywords
Characterization of a novel thermotolerant NAD+-dependent formate dehydrogenase from hot climate plant cotton (Gossypium hirsutum L.)
Sign Up to like & getrecommendations! Published in 2018 at "3 Biotech"
DOI: 10.1007/s13205-018-1200-8
Abstract: NAD+-dependent formate dehydrogenases (FDH, EC 1.2.1.2), providing energy to the cell in methylotrophic microorganisms, are stress proteins in higher plants and the level of FDH expression increases under several abiotic and biotic stress conditions. They… read more here.
Keywords: nad dependent; gossypium hirsutum; dependent formate; ghfdh1 ... See more keywords
Methanol/Oxygen Enzymatic Biofuel Cell Using Laccase and NAD+-Dependent Dehydrogenase Cascades as Biocatalysts on Carbon Nanodots Electrodes.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.7b12295
Abstract: The efficient immobilization of enzymes on favorable supporting materials to design enzyme electrodes endowed with specific catalysis performances such as deep oxidation of biofuels, and direct electron transfer (DET)-type bioelectrocatalysis is highly desired for fabricating… read more here.
Keywords: dehydrogenase; dependent dehydrogenase; dehydrogenase cascades; nad dependent ... See more keywords
A regulatory cysteine residue mediates reversible inactivation of NAD+-dependent aldehyde dehydrogenases to promote oxidative stress response.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00662
Abstract: Aldehyde dehydrogenases (ALDHs) are a large family of enzymes that oxidize aldehydes into carboxylic acids. All ALDHs have a conserved catalytic cysteine residue, but different co-factors preference for NAD+ or NADP+. We discovered a CC… read more here.
Keywords: response; cysteine; nad dependent; aldehyde dehydrogenases ... See more keywords
Structure and allosteric regulation of human NAD-dependent isocitrate dehydrogenase
Sign Up to like & getrecommendations! Published in 2020 at "Cell Discovery"
DOI: 10.1038/s41421-020-00220-7
Abstract: Human NAD-dependent isocitrate dehydrogenase or HsIDH3 catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the TCA cycle. HsIDH3 exists and functions as a heterooctamer composed of the αβ and αγ heterodimers, and is regulated allosterically… read more here.
Keywords: human nad; nad dependent; hsidh3; structure ... See more keywords
The β and γ subunits play distinct functional roles in the α2βγ heterotetramer of human NAD-dependent isocitrate dehydrogenase
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep41882
Abstract: Human NAD-dependent isocitrate dehydrogenase existing as the α2βγ heterotetramer, catalyzes the decarboxylation of isocitrate into α-ketoglutarate in the Krebs cycle, and is allosterically regulated by citrate, ADP and ATP. To explore the functional roles of… read more here.
Keywords: dependent isocitrate; human nad; nad dependent; isocitrate dehydrogenase ... See more keywords
Discovery of a new metal and NAD+-dependent formate dehydrogenase from Clostridium ljungdahlii
Sign Up to like & getrecommendations! Published in 2018 at "Preparative Biochemistry and Biotechnology"
DOI: 10.1080/10826068.2018.1446150
Abstract: ABSTRACT Over the next decades, with the growing concern of rising atmospheric carbon dioxide (CO2) levels, the importance of investigating new approaches for its reduction becomes crucial. Reclamation of CO2 for conversion into biofuels represents… read more here.
Keywords: nad dependent; clostridium ljungdahlii; co2; formate ... See more keywords
NAD Dependent Epimerase/Dehydratase Serves as a Novel Potential Target for Fluoxastrobin in Pestalotiopsis trachicarpicola, the Causal Agent of Tea Foliar Disease.
Sign Up to like & getrecommendations! Published in 2025 at "Phytopathology"
DOI: 10.1094/phyto-11-24-0357-r
Abstract: Tea foliar disease caused by the fungal pathogen Pestalotiopsis trachicarpicola poses a significant threat to tea production and quality in China. The disease, which includes tea leaf spot and gray blight, severely impacts both tea… read more here.
Keywords: tea foliar; disease; nad dependent; tea ... See more keywords
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0083
Abstract: Sirtuins are NAD+-dependent protein deacylases capable of cleaving off acetyl as well as other acyl groups from the ɛ-amino group of lysines in histones and other substrate proteins. They have been reported as promising drug… read more here.
Keywords: nad dependent; new chemical; chemical tools; lysine ... See more keywords