Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection
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DOI: 10.1016/j.expneurol.2021.113842
Abstract: SARM1 is an inducible NAD+ hydrolase that is the central executioner of pathological axon loss. Recently, we elucidated the molecular mechanism of SARM1 activation, demonstrating that SARM1 is a metabolic sensor regulated by the levels… read more here.
Keywords: nad hydrolase; sarm1; nicotinic acid; allosteric site ... See more keywords