Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity
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DOI: 10.1371/journal.pgen.1010246
Abstract: SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that SARM1 is an enzyme, SARM1… read more here.
Keywords: nadase activity; developmental signaling; activity; sarm1 ... See more keywords