NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2020.110831
Abstract: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of biological processes including energy production, DNA repair,… read more here.
Keywords: nad therapy; age related; age; nad levels ... See more keywords
Evaluation of the NAD+ biosynthetic pathway in ALS patients and effect of modulating NAD+ levels in hSOD1-linked ALS mouse models
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113219
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motor neurons. Astrocytes from diverse ALS models induce motor neuron death in co-culture. Enhancing NAD+ availability, or increasing the expression of the NAD+-dependent deacylases SIRT3… read more here.
Keywords: mouse models; effect; nad levels; nad ... See more keywords
Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Life sciences"
DOI: 10.1016/j.lfs.2022.120571
Abstract: Mitochondrial complex I (CI), the first multiprotein enzyme complex of the oxidative phosphorylation system, plays a crucial role in cellular energy production. CI deficiency is associated with a variety of clinical phenotypes, including Leigh syndrome.… read more here.
Keywords: deficiency; nad levels; nad; cellular nad ... See more keywords
Enhancing the ascorbate–glutathione cycle reduced fermentation by increasing NAD+ levels during broccoli head storage under controlled atmosphere
Sign Up to like & getrecommendations! Published in 2020 at "Postharvest Biology and Technology"
DOI: 10.1016/j.postharvbio.2020.111169
Abstract: Abstract Broccoli is prone to adopting fermentation under inappropriate conditions, especially high−CO2 atmospheres. In this study, broccoli stalks were soaked in 0.4 % reduced glutathione (GSH) for 3 h, before being maintained in 50 %… read more here.
Keywords: ascorbate glutathione; fermentation; controlled atmosphere; cycle ... See more keywords
Keeping the balance in NAD metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society transactions"
DOI: 10.1042/bst20180417
Abstract: Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of… read more here.
Keywords: balance nad; keeping balance; nad; nad levels ... See more keywords
Restoring NAD(+) Levels with NAD(+) Intermediates, the Second Law of Thermodynamics, and Aging Delay.
Sign Up to like & getrecommendations! Published in 2018 at "Rejuvenation research"
DOI: 10.1089/rej.2017.2037
Abstract: The hypothesis regarding the role of increased nicotinamide adenine dinucleotide (NAD+) levels with reference to the fundamental concepts of aging and entropy is presented. Considering the second law of thermodynamics, NAD+ seems the appropriate candidate… read more here.
Keywords: thermodynamics; second law; nad levels; law thermodynamics ... See more keywords
Interacting NAD+ and Cell Senescence Pathways Complicate Antiaging Therapies.
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DOI: 10.1089/rej.2019.2218
Abstract: During human aging, decrease of NAD+ levels is associated with potentially reversible dysfunction in the liver, kidney, skeletal and cardiac muscle, endothelial cells, and neurons. At the same time, the number of senescent cells, associated… read more here.
Keywords: senescent cells; interacting nad; senescence; nad levels ... See more keywords
Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age‐associated insulin resistance
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12798
Abstract: Nicotinamide adenine dinucleotide (NAD) is an important cofactor that regulates various biological processes, including metabolism and gene expression. As a coenzyme, NAD controls mitochondrial respiration through enzymes of the tricarboxylic acid (TCA) cycle, β‐oxidation, and… read more here.
Keywords: nad levels; associated insulin; overexpression; insulin resistance ... See more keywords
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13754
Abstract: Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of aging‐associated neurological disorders. Experimental therapies aimed at boosting brain NAD+ levels… read more here.
Keywords: plasma extracellular; extracellular vesicles; pathology; vesicles enriched ... See more keywords
Association between NAD+ levels and anaemia among women in community‐based study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17281
Abstract: Nicotinamide adenine dinucleotide (NAD+) level is the protective factor of cardiovascular diseases (CVDs). In addition, anaemia is a risk factor of adverse cardiovascular outcomes in women. However, there are limited data about the association between… read more here.
Keywords: nad levels; anaemia among; anaemia; association nad ... See more keywords
Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/2692794
Abstract: Nicotinamide adenine dinucleotide (NAD+) plays an important role in various key biological processes including energy metabolism, DNA repair, and gene expression. Accumulating clinical and experimental evidence highlights an age-dependent decline in NAD+ levels and its… read more here.
Keywords: nad metabolism; metabolism; implications nad; disease ... See more keywords