NAD+ metabolism as a target for metabolic health: have we found the silver bullet?
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4831-3
Abstract: NAD+ has gone in and out of fashion within the scientific community a number of times since its discovery in the early 1900s. Over the last decade, NAD+ has emerged as a potential target for… read more here.
Keywords: nad metabolism; metabolism; metabolic health; target metabolic ... See more keywords
A hydride transfer complex reprograms NAD metabolism and bypasses senescence.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.08.028
Abstract: Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a multi-enzymatic complex that reprograms NAD metabolism by… read more here.
Keywords: nad metabolism; complex reprograms; senescence; hydride transfer ... See more keywords
NAD+ metabolism governs the proinflammatory senescence-associated secretome
Sign Up to like & getrecommendations! Published in 2019 at "Nature cell biology"
DOI: 10.1038/s41556-019-0287-4
Abstract: Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is termed the senescence-associated secretory phenotype (SASP). NAD+ metabolism… read more here.
Keywords: nad metabolism; senescence associated; senescence; proinflammatory sasp ... See more keywords
Keeping the balance in NAD metabolism.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Society transactions"
DOI: 10.1042/bst20180417
Abstract: Research over the last few decades has extended our understanding of nicotinamide adenine dinucleotide (NAD) from a vital redox carrier to an important signalling molecule that is involved in the regulation of a multitude of… read more here.
Keywords: balance nad; keeping balance; nad; nad levels ... See more keywords
Tissue‐specific effects of exercise as NAD+‐boosting strategy: Current knowledge and future perspectives
Sign Up to like & getrecommendations! Published in 2023 at "Acta Physiologica"
DOI: 10.1111/apha.13921
Abstract: Nicotinamide adenine dinucleotide (NAD+) is an evolutionarily highly conserved coenzyme with multi‐faceted cell functions, including energy metabolism, molecular signaling processes, epigenetic regulation, and DNA repair. Since the discovery that lower NAD+ levels are a shared… read more here.
Keywords: metabolism; nad metabolism; nad boosting; tissue specific ... See more keywords
Sex‐specific alterations in NAD+ metabolism in 3xTg Alzheimer’s disease mouse brain assessed by quantitative targeted LC‐MS
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15362
Abstract: Levels of nicotinamide adenine dinucleotide (NAD+) are known to decline with age and have been associated with impaired mitochondrial function leading to neurodegeneration, a key facet of Alzheimer's disease (AD). NAD+synthesis is sustained via tryptophan‐kynurenine… read more here.
Keywords: nad metabolism; mouse brain; alzheimer disease; disease ... See more keywords
Metabolic Disease, NAD Metabolism, Nicotinamide Riboside, and the Gut Microbiome: Connecting the Dots from the Gut to Physiology
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.01223-21
Abstract: The effort to use nutrients as interventions to treat human disease has been important to medicine. A current example in this vein pertains to NAD+ boosters, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN),… read more here.
Keywords: disease; nad metabolism; physiology; gut microbiome ... See more keywords
Circadian cardiac NAD+ metabolism, from transcriptional regulation to healthy aging
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Physiology - Cell Physiology"
DOI: 10.1152/ajpcell.00239.2022
Abstract: Nicotinamide adenine dinucleotide (NAD+) is a critical redox factor and coenzyme with rhythmic availability, and reduced NAD+ levels are a common factor of many disease states, including risk factors associated with aging. Recent studies have… read more here.
Keywords: nad; nad metabolism; physiology; regulation ... See more keywords
Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/2692794
Abstract: Nicotinamide adenine dinucleotide (NAD+) plays an important role in various key biological processes including energy metabolism, DNA repair, and gene expression. Accumulating clinical and experimental evidence highlights an age-dependent decline in NAD+ levels and its… read more here.
Keywords: nad metabolism; metabolism; implications nad; disease ... See more keywords
Metabolic analyses reveal dysregulated NAD+ metabolism and altered mitochondrial state in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0273080
Abstract: Ulcerative colitis (UC) is a complex, multifactorial disease driven by a dysregulated immune response against host commensal microbes. Despite rapid advances in our understanding of host genomics and transcriptomics, the metabolic changes in UC remain… read more here.
Keywords: nad metabolism; state; metabolic analyses; ulcerative colitis ... See more keywords
The Emergence of the Nicotinamide Riboside Kinases in the regulation of NAD+ Metabolism.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-18-0085
Abstract: The concept of replenishing or elevating nicotinamide adenine dinucleotide (NAD+) availability to combat metabolic disease and ageing (described extensively in recent reviews [1, 2]) is an area of intense research. This has led to a… read more here.
Keywords: emergence nicotinamide; nad metabolism; regulation nad; nicotinamide riboside ... See more keywords