Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
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DOI: 10.1016/j.celrep.2019.07.043
Abstract: Summary Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction… read more here.
Keywords: skeletal muscle; aged human; muscle; nicotinamide riboside ... See more keywords
The Plasma NAD+ Metabolome Is Dysregulated in “Normal” Aging
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DOI: 10.1089/rej.2018.2077
Abstract: Abstract Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as an electron carrier in cellular metabolism and plays a crucial role in the maintenance of balanced redox homeostasis. Quantification of NAD+:NADH and… read more here.
Keywords: plasma; age related; age; plasma nad ... See more keywords
A Method to Monitor the NAD+ Metabolome—From Mechanistic to Clinical Applications
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DOI: 10.3390/ijms221910598
Abstract: Nicotinamide adenine dinucleotide (NAD+) and its reduced form (NADH) are coenzymes employed in hundreds of metabolic reactions. NAD+ also serves as a substrate for enzymes such as sirtuins, poly(ADP-ribose) polymerases (PARPs) and ADP-ribosyl cyclases. Given… read more here.
Keywords: monitor nad; method monitor; clinical applications; nad metabolome ... See more keywords