Efficient production of androstenedione by repeated batch fermentation in waste cooking oil media through regulating NAD+/NADH ratio and strengthening cell vitality of Mycobacterium neoaurum.
Sign Up to like & getrecommendations! Published in 2019 at "Bioresource technology"
DOI: 10.1016/j.biortech.2019.01.144
Abstract: The bioprocess for producing androstenedione (AD) from phytosterols by using Mycobacterium neoaurum is hindered by nicotinamide adenine dinucleotides (NAD+ and NADH) ratio imbalance, insoluble substrate, and lengthy biotransformation period. This study aims to improve the… read more here.
Keywords: nad nadh; cooking oil; waste cooking; mycobacterium neoaurum ... See more keywords
A unifying mechanism of ketogenic diet action: The multiple roles of nicotinamide adenine dinucleotide
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106469
Abstract: The ability of a ketogenic diet to treat seizures and render a neuronal network more resistant to strong electrical activity has been observed for a century in clinics and for decades in research laboratories. Alongside… read more here.
Keywords: nad nadh; diet action; mechanism; mechanism ketogenic ... See more keywords
Hypoxia promotes Chlamydia trachomatis L2/434/Bu growth in immortal human epithelial cells via activation of the PI3K-AKT pathway and maintenance of a balanced NAD+/NADH ratio.
Sign Up to like & getrecommendations! Published in 2020 at "Microbes and infection"
DOI: 10.1016/j.micinf.2020.04.010
Abstract: Chlamydia trachomatis LGV (CtL2) causes systemic infection and proliferates in lymph nodes as well as genital tract or rectum producing a robust inflammatory response, presumably leading to a low oxygen environment. We therefore assessed how… read more here.
Keywords: nad nadh; ctl2; growth immortal; immortal human ... See more keywords
Elucidation of a Self-Sustaining Cycle in Escherichia coli l-Serine Biosynthesis That Results in the Conservation of the Coenzyme, NAD.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00074
Abstract: The equilibrium of the reaction catalyzed by d-3-phosphoglycerate dehydrogenase (PGDH), the first enzyme in the l-serine biosynthetic pathway, is far in the direction away from serine synthesis. As such, the enzyme is usually assayed in… read more here.
Keywords: nad nadh; sustaining cycle; cycle; pathway ... See more keywords
A Single Organoiridium Complex Generating Highly Active Catalysts for both Water Oxidation and NAD+/NADH Transformations
Sign Up to like & getrecommendations! Published in 2017 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b02387
Abstract: The complex [Cp*Ir(pica)Cl] (1; pica = picolinamidate = κ2-pyridine-2-carboxamide) was found to be an effective catalyst for both water oxidation to molecular oxygen and NAD+/NADH transformations, which are the key reactions of light-dependent natural photosynthesis.… read more here.
Keywords: nad nadh; nadh transformations; water; water oxidation ... See more keywords
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00448-21
Abstract: We show that ebselen kills pathogenic C. difficile by disrupting its redox homeostasis, changing the normal concentrations of NAD+ and NADH, which are critical for various metabolic functions in cells. However, this antimicrobial action is… read more here.
Keywords: redox associated; biology; clostridioides difficile; ebselen ... See more keywords
Capsaicin Alleviates the Deteriorative Mitochondrial Function by Upregulating 14-3-3η in Anoxic or Anoxic/Reoxygenated Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/1750289
Abstract: Reactive oxygen species (ROS) are byproducts of a defective electron transport chain (ETC). The redox couples, GSH/GSSG and NAD+/NADH, play an essential role in physiology as internal defenses against excessive ROS generation by facilitating intracellular/mitochondrial… read more here.
Keywords: nad nadh; complex iii; mitochondrial function; redox ... See more keywords
A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD+/NADH+ imbalance
Sign Up to like & getrecommendations! Published in 2017 at "BMC Systems Biology"
DOI: 10.1186/s12918-017-0427-z
Abstract: BackgroundThe leading edge of the global problem of antibiotic resistance necessitates novel therapeutic strategies. This study develops a novel systems biology driven approach for killing antibiotic resistant pathogens using benign metabolites.ResultsControlled laboratory evolutions established chloramphenicol… read more here.
Keywords: nad nadh; antibiotic resistant; biology; resistance ... See more keywords
Reverse electron transfer is activated during aging and contributes to aging and age‐related disease
Sign Up to like & getrecommendations! Published in 2023 at "EMBO reports"
DOI: 10.15252/embr.202255548
Abstract: Mechanisms underlying the depletion of NAD+ and accumulation of reactive oxygen species (ROS) in aging and age‐related disorders remain poorly defined. We show that reverse electron transfer (RET) at mitochondrial complex I, which causes increased… read more here.
Keywords: age related; electron transfer; aging age; reverse electron ... See more keywords
Structural Analysis of Redox-sensing Transcriptional Repressor Rex from Thermotoga maritima.
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.2210/pdb5zz6/pdb
Abstract: The cellular redox state of organisms continues to fluctuate during the metabolism. All organisms have various sensors that help detect and adapt to changes in the redox state. Nicotinamide adenine dinucleotides (NAD+/NADH), which are involved… read more here.
Keywords: nad nadh; thermotoga maritima; redox; rex thermotoga ... See more keywords
Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.42179
Abstract: Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription… read more here.
Keywords: nad nadh; rna nad; human mitochondrial; rna ... See more keywords