Efficient production of androstenedione by repeated batch fermentation in waste cooking oil media through regulating NAD+/NADH ratio and strengthening cell vitality of Mycobacterium neoaurum.
Sign Up to like & getrecommendations! Published in 2019 at "Bioresource technology"
DOI: 10.1016/j.biortech.2019.01.144
Abstract: The bioprocess for producing androstenedione (AD) from phytosterols by using Mycobacterium neoaurum is hindered by nicotinamide adenine dinucleotides (NAD+ and NADH) ratio imbalance, insoluble substrate, and lengthy biotransformation period. This study aims to improve the… read more here.
Keywords: nad nadh; cooking oil; waste cooking; mycobacterium neoaurum ... See more keywords
A unifying mechanism of ketogenic diet action: The multiple roles of nicotinamide adenine dinucleotide
Sign Up to like & getrecommendations! Published in 2020 at "Epilepsy Research"
DOI: 10.1016/j.eplepsyres.2020.106469
Abstract: The ability of a ketogenic diet to treat seizures and render a neuronal network more resistant to strong electrical activity has been observed for a century in clinics and for decades in research laboratories. Alongside… read more here.
Keywords: nad nadh; diet action; mechanism; mechanism ketogenic ... See more keywords
Hypoxia promotes Chlamydia trachomatis L2/434/Bu growth in immortal human epithelial cells via activation of the PI3K-AKT pathway and maintenance of a balanced NAD+/NADH ratio.
Sign Up to like & getrecommendations! Published in 2020 at "Microbes and infection"
DOI: 10.1016/j.micinf.2020.04.010
Abstract: Chlamydia trachomatis LGV (CtL2) causes systemic infection and proliferates in lymph nodes as well as genital tract or rectum producing a robust inflammatory response, presumably leading to a low oxygen environment. We therefore assessed how… read more here.
Keywords: nad nadh; ctl2; growth immortal; immortal human ... See more keywords
Elucidation of a Self-Sustaining Cycle in Escherichia coli l-Serine Biosynthesis That Results in the Conservation of the Coenzyme, NAD.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry"
DOI: 10.1021/acs.biochem.8b00074
Abstract: The equilibrium of the reaction catalyzed by d-3-phosphoglycerate dehydrogenase (PGDH), the first enzyme in the l-serine biosynthetic pathway, is far in the direction away from serine synthesis. As such, the enzyme is usually assayed in… read more here.
Keywords: nad nadh; sustaining cycle; cycle; pathway ... See more keywords
A Single Organoiridium Complex Generating Highly Active Catalysts for both Water Oxidation and NAD+/NADH Transformations
Sign Up to like & getrecommendations! Published in 2017 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b02387
Abstract: The complex [Cp*Ir(pica)Cl] (1; pica = picolinamidate = κ2-pyridine-2-carboxamide) was found to be an effective catalyst for both water oxidation to molecular oxygen and NAD+/NADH transformations, which are the key reactions of light-dependent natural photosynthesis.… read more here.
Keywords: nad nadh; nadh transformations; water; water oxidation ... See more keywords
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00448-21
Abstract: We show that ebselen kills pathogenic C. difficile by disrupting its redox homeostasis, changing the normal concentrations of NAD+ and NADH, which are critical for various metabolic functions in cells. However, this antimicrobial action is… read more here.
Keywords: redox associated; biology; clostridioides difficile; ebselen ... See more keywords
Cellular Redox Status of Dermal fibroblasts as a Model to Explore Hypoxia Responses Across Diverse Mammals
Sign Up to like & getrecommendations! Published in 2024 at "Physiology"
DOI: 10.1152/physiol.2024.39.s1.2220
Abstract: Specializations in energy production pathways can define phenotype in mammals, enabling resilience to environmental stressors and survival in extreme habitats. Most mammals rely on oxygen-based mitochondrial respiration to sustain high rates of ATP production necessary… read more here.
Keywords: redox; oxygen; physiology; nad nadh ... See more keywords
Capsaicin Alleviates the Deteriorative Mitochondrial Function by Upregulating 14-3-3η in Anoxic or Anoxic/Reoxygenated Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2020 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2020/1750289
Abstract: Reactive oxygen species (ROS) are byproducts of a defective electron transport chain (ETC). The redox couples, GSH/GSSG and NAD+/NADH, play an essential role in physiology as internal defenses against excessive ROS generation by facilitating intracellular/mitochondrial… read more here.
Keywords: nad nadh; complex iii; mitochondrial function; redox ... See more keywords
TSA attenuates the progression of c-Myc-driven hepatocarcinogenesis by pAKT-ADH4 pathway
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-12781-x
Abstract: Hepatocellular carcinoma (HCC) is the primary malignant tumor of the liver. c-Myc is one of the most common oncogenes in clinical settings, and amplified levels of c-Myc are frequently found in HCC. Histone deacetylase inhibitors… read more here.
Keywords: treatment; tsa; hcc; nad nadh ... See more keywords
A scalable metabolite supplementation strategy against antibiotic resistant pathogen Chromobacterium violaceum induced by NAD+/NADH+ imbalance
Sign Up to like & getrecommendations! Published in 2017 at "BMC Systems Biology"
DOI: 10.1186/s12918-017-0427-z
Abstract: BackgroundThe leading edge of the global problem of antibiotic resistance necessitates novel therapeutic strategies. This study develops a novel systems biology driven approach for killing antibiotic resistant pathogens using benign metabolites.ResultsControlled laboratory evolutions established chloramphenicol… read more here.
Keywords: nad nadh; antibiotic resistant; biology; resistance ... See more keywords
The synergism of cytosolic acidosis and reduced NAD+/NADH ratio is responsible for lactic acidosis-induced vascular smooth muscle cell impairment in sepsis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-023-00992-6
Abstract: During sepsis, serve vascular dysfunctions lead to life-threatening multiple organ failure, due to vascular smooth muscle cells (VSMC) impairments, resulting in vasoplegia, hypotension and hypoperfusion. In addition, septic patients have an altered cell metabolism that… read more here.
Keywords: nad nadh; smooth muscle; lactate; lactic acidosis ... See more keywords