The NAD+ precursor NMN activates dSarm to trigger axon degeneration in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.01.30.478002
Abstract: Axon degeneration contributes to the disruption of neuronal circuit function in diseased and injured nervous systems. Severed axons degenerate following the activation of an evolutionarily conserved signaling pathway, which culminates in the activation of SARM1… read more here.
Keywords: nad precursor; degeneration; axon degeneration; nmn ... See more keywords
Dihydronicotinamide Riboside Is a Potent NAD+ Precursor Promoting a Pro-Inflammatory Phenotype in Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.840246
Abstract: Nicotinamide adenine dinucleotide (NAD) metabolism plays an important role in the regulation of immune function. However, a complete picture of how NAD, its metabolites, precursors, and metabolizing enzymes work together in regulating immune function and… read more here.
Keywords: inflammatory phenotype; nad precursor; potent nad; pro inflammatory ... See more keywords