NAD+ salvage governs mitochondrial metabolism invigorating NK cell anti-tumor immunity.
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DOI: 10.1002/hep.32658
Abstract: BACKGROUND & AIMS Natural killer (NK) cells are key players in tumor immunosurveillance and metabolic adaption manipulates their fate and functional state. The nicotinamide adenine dinucleotide (NAD+ ) has emerged as a vital factor to… read more here.
Keywords: salvage; cell; metabolism; anti tumor ... See more keywords
The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis.
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DOI: 10.1016/j.celrep.2018.07.086
Abstract: NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein,… read more here.
Keywords: serine biosynthesis; salvage pathway; nad salvage; salvage ... See more keywords
Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival
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DOI: 10.1371/journal.ppat.1008539
Abstract: NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for de novo NAD biosynthesis, we evaluated whether these parasites, which infect >200… read more here.
Keywords: metabolism; salvage pathway; pathway schistosomes; inhibition nad ... See more keywords