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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.

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1 Published in 2021 at "Cell reports"

DOI: 10.1016/j.celrep.2021.109516

Abstract: Although tumor-infiltrating lymphocytes (TILs) maintain their ability to proliferate, persist, and eradicate tumors, they are frequently dysfunctional in situ. By performing both whole-genome CRISPR and metabolic inhibitor screens, we identify that nicotinamide phosphoribosyltransferase (NAMPT) is… read more here.

Keywords: tumor killing; tub; nad supplement; function ... See more keywords