Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.03.018
Abstract: The redox cofactor nicotinamide adenine dinucleotide (NAD) plays a central role in metabolism and is a substrate for signaling enzymes including poly-ADP-ribose-polymerases (PARPs) and sirtuins. NAD concentration falls during aging, which has triggered intense interest… read more here.
Keywords: synthesis breakdown; nad synthesis; metabolism; analysis ... See more keywords
Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2020.05.010
Abstract: The numerous biological roles of NAD+ are organized and coordinated via its compartmentalization within cells. The spatial and temporal partitioning of this intermediary metabolite is intrinsic to understanding the impact of NAD+ on cellular signaling… read more here.
Keywords: location compartmentalization; location location; location; nad synthesis ... See more keywords
Impact of Nuclear De Novo NAD+ Synthesis via Histone Dynamics on DNA Repair during Cellular Senescence To Prevent Tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00379-22
Abstract: NAD+ synthesis is a fundamental process in living cells. The effects of local metabolite production on chromatin influence the epigenetic status of chromatin in DNA metabolism. ABSTRACT NAD+ synthesis is a fundamental process in living… read more here.
Keywords: novo nad; nad synthesis; cellular senescence; repair ... See more keywords
Targeting Nuclear NAD+ Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells
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DOI: 10.3390/cancers12051180
Abstract: Osteosarcoma (OS) is the most common bone tumor in children and adolescents. Modern OS treatment, based on the combination of neoadjuvant chemotherapy (cisplatin + doxorubicin + methotrexate) with subsequent surgical removal of the primary tumor… read more here.
Keywords: nad synthesis; osteosarcoma; osteosarcoma cells; 2os osteosarcoma ... See more keywords
Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105787
Abstract: The IDH1R132H mutation in glioma results in the neoenzymatic function of IDH1, leading to the production of the oncometabolite 2-hydroxyglutarate (2-HG), alterations in energy metabolism and changes in the cellular redox household. Although shifts in… read more here.
Keywords: idh mutant; nad synthesis; glioma; wild type ... See more keywords