Bifunctional NadC Homologue PyrZ Catalyzes Nicotinic Acid Formation in Pyridomycin Biosynthesis.
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DOI: 10.1021/acschembio.2c00773
Abstract: Pyridomycin is a potent antimycobacterial natural product by specifically inhibiting InhA, a clinically validated antituberculosis drug discovery target. Pyridyl moieties of pyridomycin play an essential role in inhibiting InhA by occupying the reduced form of… read more here.
Keywords: nadc homologue; nicotinic acid; acid; formation ... See more keywords