Imidazole and nitroimidazole derivatives as NADH‐fumarate reductase inhibitors: Density functional theory studies, homology modeling, and molecular docking
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DOI: 10.1002/jcc.26959
Abstract: Chagas disease is caused by Trypanosoma cruzi. Benznidazole and nifurtimox are drugs used for its therapy; nevertheless, they have collateral effects. NADH‐fumarate (FUM) reductase is a potential pharmacological target since it is essential for survival… read more here.
Keywords: fum reductase; nadh fum; nitroimidazole derivatives; imidazole nitroimidazole ... See more keywords