Simulations of Shikimate Dehydrogenase from Mycobacterium tuberculosis in Complex with 3-Dehydroshikimate and NADPH Suggest Strategies for MtbSDH Inhibition
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DOI: 10.1021/acs.jcim.8b00834
Abstract: Shikimate dehydrogenase (SDH) from Mycobacterium tuberculosis ( MtbSDH), encoded by the aroE gene, is essential for viability of M. tuberculosis but absent from humans. Therefore, it is a potentially promising target for antituberculosis agent development.… read more here.
Keywords: shikimate dehydrogenase; nadph; mtbsdh; nadph binding ... See more keywords