Short-lived neutral FMN and FAD semiquinones are transient intermediates in cryo-reduced yeast NADPH-cytochrome P450 reductase.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108080
Abstract: The electron configuration of flavin cofactors, FMN and FAD, is a critical factor governing the reactivity of NADPH-cytochrome P450 reductase (CPR). The current view of electron transfer by the mammalian CPR, based on equilibrium redox… read more here.
Keywords: nadph cytochrome; fmn fad; fad; electron ... See more keywords
Cloning and Expression of NADPH-cytochrome P450 Reductase Gene in Chinese Mitten Crab, Eriocheir sinensis
Sign Up to like & getrecommendations! Published in 2021 at "Brazilian Archives of Biology and Technology"
DOI: 10.1590/1678-4324-2021210292
Abstract: HIGHLIGHTS EsCPR was isolated from E. sinensis using RT-PCR and RACE methods. EsCPR mRNA was markedly expressed in the hepatopancreas and stomach of E. sinensis. The results showed a higher CPR expression level in the… read more here.
Keywords: sinensis; nadph cytochrome; expression; cloning expression ... See more keywords
Comparative Analysis of NADPH-Cytochrome P450 Reductases From Legumes for Heterologous Production of Triterpenoids in Transgenic Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.762546
Abstract: Triterpenoids are plant specialized metabolites with various pharmacological activities. They are widely distributed in higher plants, such as legumes. Because of their low accumulation in plants, there is a need for improving triterpenoid production. Cytochrome… read more here.
Keywords: cytochrome p450; class; production; nadph cytochrome ... See more keywords
Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9080673
Abstract: Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH–cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical… read more here.
Keywords: nadph cytochrome; heme; p450 oxidoreductase; cpr ... See more keywords
NADPH–Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from Mortierella alpina
Sign Up to like & getrecommendations! Published in 2022 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb44050125
Abstract: Fatty acid desaturases play an important role in maintaining the appropriate structure and function of biological membranes. The biochemical characterization of integral membrane desaturases, particularly ω3 and ω6 desaturases, has been limited by technical difficulties… read more here.
Keywords: cytochrome p450; fatty acid; p450 reductase; nadph cytochrome ... See more keywords