NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00326-0
Abstract: Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions and redox balance. NADPH homeostasis is regulated by varied signaling pathways and several metabolic… read more here.
Keywords: nadph homeostasis; therapeutic implications; homeostasis cancer; cancer cells ... See more keywords
Control Analysis of Cooperativity and Complementarity in Metabolic Regulations: The Case of NADPH Homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Metabolites"
DOI: 10.3390/metabo13040485
Abstract: Complex feedback regulation patterns shape the cellular metabolic response to external or internal perturbations. We propose here a framework consisting of a sampling-based metabolic control analysis of kinetic models to investigate the modes of regulatory… read more here.
Keywords: analysis cooperativity; control analysis; regulation; nadph homeostasis ... See more keywords