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Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.090878
Abstract: Pyrrolo[2,1-c][1,4]benzodiazepine dimer (PBD) has shown broad antitumor properties and potential as a therapeutic agent for cancers. During a routine drug-drug interaction assessment, it was found that PBD is a reversible inhibitor of CYP2C8 (IC50 =…
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Keywords:
cyp2b6;
inhibition;
nadph independent;
inactivation ... See more keywords