Epithelium-autonomous NAIP/NLRC4 prevents TNF-driven inflammatory destruction of the gut epithelial barrier in Salmonella-infected mice
Sign Up to like & getrecommendations! Published in 2021 at "Mucosal Immunology"
DOI: 10.1038/s41385-021-00381-y
Abstract: The gut epithelium is a critical protective barrier. Its NAIP/NLRC4 inflammasome senses infection by Gram-negative bacteria, including Salmonella Typhimurium (S.Tm) and promotes expulsion of infected enterocytes. During the first ~12–24 h, this reduces mucosal S.Tm loads… read more here.
Keywords: naip nlrc4; barrier; autonomous naip; epithelium autonomous ... See more keywords
Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers
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DOI: 10.1073/pnas.2013963118
Abstract: Significance Contractile movements in the mammalian intestine typically rely on dedicated muscle cells. Here, we however show that untransformed intestinal epithelial cell layers initiate immediate focal contractions, affecting hundreds to thousands of epithelial cells, in… read more here.
Keywords: epithelial cell; naip nlrc4; intestinal epithelial; focal contractions ... See more keywords
Salmonella enterica Serovar Typhimurium Induces NAIP/NLRC4- and NLRP3/ASC-Independent, Caspase-4-Dependent Inflammasome Activation in Human Intestinal Epithelial Cells
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DOI: 10.1128/iai.00663-21
Abstract: Salmonella enterica serovar Typhimurium is a Gram-negative pathogen that causes diseases ranging from gastroenteritis to systemic infection and sepsis. Salmonella uses type III secretion systems (T3SS) to inject effectors into host cells. While these effectors… read more here.
Keywords: serovar typhimurium; salmonella; naip nlrc4; enterica serovar ... See more keywords