Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome
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DOI: 10.1371/journal.ppat.1006502
Abstract: Legionella pneumophila is a Gram-negative, flagellated bacterium that survives in phagocytes and causes Legionnaires’ disease. Upon infection of mammalian macrophages, cytosolic flagellin triggers the activation of Naip/NLRC4 inflammasome, which culminates in pyroptosis and restriction of… read more here.
Keywords: caspase; caspase activation; asc inflammasome; naip5 nlrc4 ... See more keywords