Improving naive B cell isolation by absence of CD45RB glycosylation and CD27 expression in combination with BCR isotype
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202250013
Abstract: In past years ex vivo and in vivo experimental approaches involving human naive B cells have proven fundamental for elucidation of mechanisms promoting B cell differentiation in both health and disease. For such studies, it… read more here.
Keywords: cell; naive cell; cell isolation; naive cells ... See more keywords
The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat0381
Abstract: Inspection of the naive B cell repertoire specific for an HIV vaccine immunogen provides actionable information for human vaccine design and advancement. Learning from naive B cells Despite decades of intensive research, HIV vaccines are… read more here.
Keywords: cell repertoire; human naive; naive cell; vaccine ... See more keywords
258-LB: Vitamin D Directly Regulates TRPV1 Channel Activity and May Play an Important Role in the Autoimmune Disease of Type 1 Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-258-lb
Abstract: The autoimmune disease of type 1 diabetes (T1D) results in the immune destruction of β-cells. Recent studies suggest supplementation of vitamin D along can significantly improve patients’ β-cell function and glycemic control possibly by dampening… read more here.
Keywords: activation; none; cell activation; autoimmune disease ... See more keywords
How Naive T-Cell Clone Counts Are Shaped By Heterogeneous Thymic Output and Homeostatic Proliferation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.735135
Abstract: The specificity of T cells is that each T cell has only one T cell receptor (TCR). A T cell clone represents a collection of T cells with the same TCR sequence. Thus, the number… read more here.
Keywords: naive cell; clone; proliferation; cell clone ... See more keywords
The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.49900
Abstract: The clone size distribution of the human naive T-cell receptor (TCR) repertoire is an important determinant of adaptive immunity. We estimated the abundance of TCR sequences in samples of naive T cells from blood using… read more here.
Keywords: repertoire; cell; cell receptor; tcr sequences ... See more keywords