Small RNA sequencing in hypoxic naked mole‐rat hearts suggests microRNA regulation of RNA‐ and translation‐related processes
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14499
Abstract: The naked mole‐rat (Heterocephalus glaber) regularly endures intermittent periods of hypoxia in its burrows, surviving in part due to metabolic rate depression (MRD)—a strategy of conserving cellular resources by downregulating nonessential gene expression and reorganizing cellular… read more here.
Keywords: rna sequencing; naked mole; translation related; small rna ... See more keywords
Caveolin‐1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole‐rats
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11890
Abstract: Naked mole‐rats (NMRs) (Heterocephalus glaber) are highly social and subterranean rodents with large communal colonies in burrows containing low oxygen levels. The inhibition of severe hypoxic conditions is of particular interest to this study. To… read more here.
Keywords: naked mole; nmr hippocampal; hypoxia; cav ... See more keywords
Atg5-mediated autophagy controls apoptosis/anoikis via p53/Rb pathway in naked mole-rat fibroblasts.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.083
Abstract: The naked mole-rat (NMR, Heterocephalus glaber) is the longest-living known rodent species, with a maximum lifespan of over 30 years. NMRs exhibit negligible senescence, exceptional resistance to cancer, and high basal autophagy activity compared with… read more here.
Keywords: apoptosis; mole rat; naked mole; apoptosis anoikis ... See more keywords
Supermole-rat to the rescue: Does the naked mole-rat offer a panacea for all that ails us?
Sign Up to like & getrecommendations! Published in 2022 at "Comparative biochemistry and physiology. Part A, Molecular & integrative physiology"
DOI: 10.1016/j.cbpa.2021.111139
Abstract: Over the previous several decades, many non-traditional research models have offered new avenues of exploration for biomedical research. The promise of these animals is primarily derived from adaptations to unique or challenging environments that share… read more here.
Keywords: naked mole; rescue naked; rat; rat rescue ... See more keywords
Effects of dexamethasone and acetylsalicylic acid on inflammation caused by Complete Freund's adjuvant in the naked mole rat (Heterocephalus glaber)
Sign Up to like & getrecommendations! Published in 2022 at "Heliyon"
DOI: 10.1016/j.heliyon.2022.e08920
Abstract: The naked mole rat (NMR) is a fossorial rodent that has been observed to have a unique nociceptive system in comparison to others. In this study, we explored on characterization of chronic inflammation in the… read more here.
Keywords: naked mole; acetylsalicylic acid; complete freund; dexamethasone acetylsalicylic ... See more keywords
Characterization of multilamellar bodies and telocytes within the testicular interstitium of naked mole rat Heterocephalus glabe.
Sign Up to like & getrecommendations! Published in 2019 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2019.07.010
Abstract: Multilamellar bodies (MLBs) are produced and secreted by many cell types. In this study, we report the existence and ultrastructure of MLBs that are produced by Leydig cells and identification of telocytes in the testicular… read more here.
Keywords: testicular interstitium; microscopy; naked mole; mlbs ... See more keywords
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16050-w
Abstract: Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is unclear if exceptional polymer length of vHMM-HA is important for longevity. Here, we show that vHMM-HA (>6.1… read more here.
Keywords: naked mole; high molecular; mass hyaluronan; molecular mass ... See more keywords
Unraveling the gut microbiome of the long-lived naked mole-rat
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-10287-0
Abstract: The naked mole-rat (Heterocephalus glaber) is a subterranean mouse-sized African mammal that shows astonishingly few age-related degenerative changes and seems to not be affected by cancer. These features make this wild rodent an excellent model… read more here.
Keywords: naked mole; gut microbiome; biology; mole rat ... See more keywords
Unprovoked Stabilization and Nuclear Accumulation of the Naked Mole-Rat p53 Protein
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64009-0
Abstract: The naked mole-rat is a subterranean rodent, approximately the size of a mouse, renowned for its exceptional longevity (>30 years) and remarkable resistance to cancer. To explore putative mechanisms underlying the cancer resistance of the… read more here.
Keywords: naked mole; p53 protein; mole rat;
Characterization of an active LINE-1 in the naked mole-rat genome
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84962-8
Abstract: Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-living rodent species. A reason for their long lifespan is pronounced cancer resistance. Therefore, researchers believe that NMRs have unknown secrets of cancer resistance and seek to find… read more here.
Keywords: nmr genome; cancer resistance; naked mole; retrotransposition ... See more keywords
Abundance and size of hyaluronan in naked mole-rat tissues and plasma
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-86967-9
Abstract: Large amounts of ultra-high molecular weight hyaluronan (HA) have been described as the main cause of cancer resistance in naked mole-rats (Heterocephalus glaber, NMR). Our work examined HA metabolism in these rodents more closely. HA… read more here.
Keywords: weight; hyaluronan; naked mole; high molecular ... See more keywords