Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants
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DOI: 10.1136/archdischild-2022-323807
Abstract: Objectives Intranasal nalbuphine could be a safe, efficacious and non-invasive alternative to parenteral pain medication in infants. We aimed to assess pharmacokinetics (PK) and tolerability of intranasal and intravenous nalbuphine administration in infants. Methods Prospective… read more here.
Keywords: administration; pharmacokinetics tolerability; tolerability intranasal; intranasal intravenous ... See more keywords
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Nalbuphine ER Tablets for Uremic Pruritus
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DOI: 10.1159/000484573
Abstract: Background: Pruritus is a distressing hallmark of the uremic condition, affecting approximately 60% of hemodialysis patients. Abnormal endogenous opioid ligand activity at μ and κ-opioid receptors has been postulated as a mechanism in uremic pruritus.… read more here.
Keywords: pruritus; controlled trial; uremic pruritus; nal 120 ... See more keywords
To assess the efficacy of injection nalbuphine as an adjuvant to intrathecal bupivacaine in endoscopic urological surgeries for prolongation of postoperative analgesia
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DOI: 10.12688/f1000research.133274.1
Abstract: Spinal anesthesia has a quicker onset of action and completely blocks all motor functions. It requires less local anesthetic and has a reduced rate of failed blocks hence the preferred anesthetic method for lower abdomen… read more here.
Keywords: analgesia; nalbuphine; bupivacaine endoscopic; intrathecal bupivacaine ... See more keywords