High-dose naloxone, an experimental tool uncovering latent sensitisation: pharmacokinetics in humans.
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DOI: 10.1016/j.bja.2018.12.007
Abstract: BACKGROUND Naloxone, an opioid receptor antagonist, is used as a pharmacological tool to detect tonic endogenous activation of opioid receptors in experimental pain models. We describe a pharmacokinetic model linking naloxone pharmacokinetics to its main… read more here.
Keywords: infusion; naloxone experimental; dose naloxone; model ... See more keywords