Long‐term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone‐precipitated withdrawal
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DOI: 10.1016/j.lfs.2017.07.016
Abstract: Aims: Slow‐release morphine sulfate pellets and osmotic pumps are common routes of chronic morphine delivery in mouse models, but direct comparisons of these drug delivery systems are lacking. In this study, we assessed the efficacy… read more here.
Keywords: morphine; delivery; osmotic pumps; slow release ... See more keywords
Inhibition of the lateral habenular CaMKⅡ abolishes naloxone-precipitated conditioned place aversion in morphine-dependent mice
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DOI: 10.1016/j.neulet.2017.05.027
Abstract: Addictive substances mediate positive and negative states promoting compulsive drug use. However, substrates for aversive effects of drugs are not fully understood. We found that inactivation of the lateral habenula (LHb) by microinjection of tetrodotoxin… read more here.
Keywords: morphine; morphine dependent; naloxone precipitated; precipitated conditioned ... See more keywords
Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice
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DOI: 10.1016/j.neuropharm.2017.03.029
Abstract: ABSTRACT Hydrogen therapy is a new medical approach for a wide range of diseases. The effects of hydrogen on central nervous system‐related diseases have recently become increasingly appreciated, but little is known about whether hydrogen… read more here.
Keywords: hydrogen; anxiety like; like behaviors; naloxone precipitated ... See more keywords