PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2018.10.108
Abstract: Exposure to ambient fine particular matter (PM2.5) has been clearly associated with male reproductive disorders. However, very limited toxicological studies were carried out to investigate the potential mechanisms underlying the PM2.5-induced sperm quality decline. In… read more here.
Keywords: sperm quality; nalp3 inflammasome; exposure; pm2 exposure ... See more keywords
Human periodontal ligament stem cells secretome from multiple sclerosis patients suppresses NALP3 inflammasome activation in experimental autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Immunopathology and Pharmacology"
DOI: 10.1177/0394632017722332
Abstract: Research in recent years has largely explored the immunomodulatory effects of mesenchymal stem cells (MSCs) and their secretory products, called “secretome,” in the treatment of neuroinflammatory diseases. Here, we examined whether such immunosuppressive effects might… read more here.
Keywords: conditioned medium; stem cells; nalp3 inflammasome; experimental autoimmune ... See more keywords