Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a.
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DOI: 10.1002/jcp.30532
Abstract: Maternal aging can impair the quality and decrease the developmental competence of ovulated oocytes. In this study, compromised germinal vesicle breakdown (GVBD) was found in aged mice oocytes. Furthermore, we observed increased reactive oxygen species… read more here.
Keywords: mitochondrial function; foxo3a; affects mitochondrial; nampt affects ... See more keywords